Results 131 to 140 of about 4,033,045 (310)

The strategic fit of supply chain integration in the TFT-LCD industry [PDF]

open access: yes, 2010
[[abstract]]Purpose - The purpose of this paper is to identify what kind of supply chain integration strategies can support TFT-LCD manufacturers seeking to break through the cost constraints and complex co-operation relationships between manufacturers ...
沙永傑; D.Y.Sha; P.K.Chen; 陳永信; Chen, Yung-Hsin
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Influence of Different Phase Angles on Polygon Effect of Long Pitch Conveyor Chain

open access: yesJixie chuandong, 2019
The slideway restrained conveyor chain is a new type of chain drive configuration. Reasonable selection of various parameters is conducive to improving the performance of the chain.
Guojin Wang, Lin Hong, Yanshu Liang
doaj  

Ladder Chains: A Variation of Random Walks

open access: yes, 2018
14 pages, 2 ...
Zhang, Chenhe, Fang, Xiang
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

AI in supply chain: Techniques, applications, real-world cases and benefits under SCOR framework [PDF]

open access: yes
This article focuses on practical perspectives of Artificial Intelligence (AI) applications in Supply Chain Management by exploring commonly used AI techniques, use cases and benefits of applying AI in Supply Chain Management with real-world examples ...
Briš, Petr, Pham Hoang, Bao
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Power and bipower variation with stochastic volatility and jumps [PDF]

open access: yes
This paper shows that realised power variation and its extension we introduce here called realised bipower variation is somewhat robust to rare jumps.
Neil Shephard, Ole E. Barndorff-Nielsen
core  

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