Results 191 to 200 of about 3,527,028 (317)

Real-world feasibility of adapted European Respiratory Society asthma diagnosis guidelines for school-aged children. [PDF]

ERJ Open Res
Sasaki M, Goutaki M, Glick S, Blanchon S, Hoyler K, Latzin P, Moeller A, Regamey N, Kuehni CE, SPAC Study Team.   +9 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Effects of game interactivity on perceived emotional challenge, mixed-affect emotional experiences and physiological responses. [PDF]

Front Psychol
Gao T, Song Q, Xie X, He J, Peng X, Huang J, Chen H, Wang C.   +7 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Establishment and optimization of an <i>E. coli</i> urinary tract infection model in Göttingen minipigs with strain recovery and characterization. [PDF]

Front Immunol
Lübbers J, Orlandini K, Podob E, Fernandez J, Wilson JM, van Heerden M, Zeijpveld J, van Kregten J, Buckley PT, van den Dobbelsteen G, Bair KL.   +10 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

CircRNA based bi-antigen vaccines against mpox virus induce potent and durable cross-protection in mice. [PDF]

Mol Biomed
Zhou J, Wang C, Wu Y, Zhao B, Yang Y, Ye T, Zhang K, Li F, Hu J, Zhang K, Liu F, Wang W, Wang C, Wang Z, Chuai X, Chiu S.   +15 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Challenge, Vol. 16, Issue 1

, 2020
Mukenge, Ida Rousseau
core  

The Challenge Program on Water and Food: Volta Basin Development Challenge Inception Workshop Report [PDF]

, 2013
CGIAR Challenge Program on Water and Food
core