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The Challenges of Challenge Experiments

New England Journal of Medicine, 2014
Challenge experiments involving infecting healthy human subjects to test the efficacy of a new vaccine can be invaluable, but historically, researchers sometimes undertook such efforts with little attention to ethical concerns raised by purposefully making people sick.
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Fibrolamellar carcinoma: Challenging the challenge

European Journal of Cancer, 2020
Fibrolamellar carcinoma (FLC) is a rare and poorly understood malignancy, which seems to be more prevalent in young patients compared with conventional hepatocellular carcinoma (HCC). Performing prospective clinical trials recruiting patients diagnosed with FLC has proven challenging with scarce data available guiding clinical management.
Angela Lamarca   +7 more
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Challenges

ACM SIGART Bulletin, 1983
It is the intent of this article to push beyond the horizon of "current survey and future work," with a set of mildly outrageous long-term challenges. The targeted areas are expert systems, problem solving and learning. Somewhere between AAAI-82 and science fiction, our future research projects lie.
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