Results 111 to 120 of about 13,780,988 (298)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

2017 Sustainable LA Grand Challenge Research Symposium Program [PDF]

, 2017
On May 17, 2017, Sustainable LA Grand Challenge (SLA GC) hosted their first symposium showcasing cutting-edge research toward the goal of 100% renewable energy, 100% locally sourced water, and enhanced ecosystem and human health in Los Angeles County by ...
Sustainable LA Grand Challenge
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Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Protocol for a double-blind crossover randomised controlled trial to investigate inhalation challenge to assess inducible laryngeal obstruction: CH-ILO

ERJ Open Research
Introduction Inducible laryngeal obstruction (ILO) remains a poorly understood condition in part due to lack of understanding about the underlying neuronal mechanisms. Many suffer delayed confirmed diagnosis as no standardised assessment exists. Based on
Jemma Haines, Maria G. Belvisi, Eric C. Dubuis, Rachel J. Dockry, Kimberley J. Holt, James H. Hull, Janelle Yorke, Stephen J. Fowler, Jaclyn Ann Smith   +8 more
doaj   +1 more source

Summary of CCI Summit outcomes : outcomes of the Caribbean Summit of Political and Business Leaders to launch the second phase of the Caribbean Challenge Initiative (CCI) [PDF]

, 2013
To accelerate marine conservation action in the Caribbean, a second phase of the Caribbean Challenge Initiative (CCI) was launched at a Summit of Caribbean Political and Business Leaders. The Summit was co-hosted by Dr. The Right Hon. Keith C.
Caribbean Challenge Initiative (CCI)
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

South Carolina Youth Challenge Academy Wellness Policy

, 2022
The South Carolina Youth Challenge Academy (SCYCA) Wellness Committee recognizes that cadet wellness and proper nutrition are related to their physical wellbeing, growth, development, and readiness to learn.
South Carolina Youth Challenge Academy
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Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Green Lunchroom Challenge Baseline Form [PDF]

, 2016
Form for Green Lunchroom Challenge participants to collect baseline facility data.Open Restriction set for Item 106217 on 2018-07-10T21:10:06Z with date null by l-barnes@illinois.edu.Submitted by Laura Barnes (l-barnes@illinois.edu) on 2018-07-10T21:13 ...

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