Results 151 to 160 of about 4,304,349 (326)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Stoch-aptation: a new term in the science of evolution
Ideas in Ecology and Evolution, 2015 Following two seminal papers published in Paleobiology by Stephen Jay Gould and Elisabeth Vrba several decades ago, I suggest a new term (stoch-aptation) to refer to those individual traits or sets of traits that provide, just by chance, fitness ...
Alejandro Martínez Abraín
doaj
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Would You Do Your Homework for a Chance to Improve Your Quiz Score? [PDF]
, 2014 Karl J. Zimmerman
openalex +1 more source
»Du hast keine Chance, aber nutze sie!« Eine philosophische Kulturgeschichte bayerischen Eigensinns
, 2023 Josef Früchtl
openalex +1 more source
Measurement of H2O and other trace gases in the stratosphere using a high resolution far-infrared spectrometer at 28 km [PDF]
Data analysis results from the 1983 BIC 1 and 2 balloon flights are presented, with emphasis on H2O2, OH, HCL, O3, O2, and H2O. A 2 sigma limit on H2O2 abundance was set, as a function of altitude.
Chance, K. V., Traub, W. A.
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Hume e as bases científicas da tese de que não há acaso no mundo
Principia: An International Journal of Epistemology, 2012 Both in the Treatise of Human Nature and in the Enquiry concerning Human Understanding, Hume defends that “there is no chance in the world”, and that “what the vulgar call chance is nothing but a secret and conceal’d cause”.
Silvio Seno Chibeni
doaj