Results 111 to 120 of about 2,607,610 (251)

Change Detection in Point Clouds Using 3D Fractal Dimension

Remote Sensing
The management of large point clouds obtained by LiDAR sensors is an important topic in recent years due to the widespread use of this technology in a wide variety of applications and the increasing volume of data captured.
Juan C. Casas-Rosa, Pablo Navarro, Rafael J. Segura-Sánchez, Antonio J. Rueda-Ruiz, Alfonso López-Ruiz, José M. Fuertes, Claudio Delrieux, Carlos J. Ogayar-Anguita   +7 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Differentially Private Change-Point Detection

, 2018
The change-point detection problem seeks to identify distributional changes at an unknown change-point k* in a stream of data. This problem appears in many important practical settings involving personal data, including biosurveillance, fault detection, finance, signal detection, and security systems.
Cummings, Rachel, Krehbiel, Sara, Mei, Yajun, Tuo, Rui, Zhang, Wanrong   +4 more
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Bootstrap for change point detection

, 2017
In Change point detection task Likelihood Ratio Test (LRT) is sequentially applied in a sliding window procedure. Its high values indicate changes of parametric distribution in the data sequence. Correspondingly LRT values require predefined bound for their maximum.
Buzun, Nazar, Avanesov, Valeriy
openaire   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A Bayesian change point detection-based method for rolling bearing remaining useful life prediction

Advances in Mechanical Engineering
Addressing the multi-stage characteristics of rolling bearing degradation with random change points, this paper proposes a novel method for predicting the Remaining Useful Life (RUL) of multi-stage degradation processes.
Wenping Lei, Wangshen Hao, Chenyang Li, Yifei Zhang   +3 more
doaj   +1 more source

Bayesian multiple changing-points detection

AIMS Mathematics
This study investigated the application of Bayesian multiple change-point detection techniques in the context of piecewise polynomial signals. Given the limited number of existing methodologies for identifying change-points in such signals, we proposed an objective Bayesian change-point detection approach that accommodated heterogeneous error ...
Sang Gil Kang, Woo Dong Lee, Yongku Kim
openaire   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source