Results 231 to 240 of about 10,495,914 (268)

"We were caught sleeping": formulation of national policy to decentralise management of drug-resistant tuberculosis in South Africa - a qualitative policy analysis study. [PDF]

BMJ Open
Moshabela M, Dickson L, Jassat W, Cox H, Kielmann K, Loveday M, Black J, Mlisana K, Nicol MP, Grant AD.   +9 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Moving percentage of failed delta checks: a novel patient-based quality control model. [PDF]

Biochem Med (Zagreb)
Yilmaz NS, Sen B, Turkmen S, Çubukçu HC, Gulbahar O.   +4 more
europepmc   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

GSOCS-LULCC: A Global dataset of Soil Organic Carbon Stock dynamics following Land Use and Land Cover Change. [PDF]

Sci Data
Shuai Q, Jin D, Arrouays D, Chen Z, Dai L, Du Y, Hong Y, Hu B, Huang Y, Ji W, Li S, Liang Z, Ma Y, Richer-de-Forges AC, Schillaci C, Shi Z, Su Y, Teng H, Wang N, Wang X, Wang Y, Wang Z, Wang Z, Xu D, Xue J, Ye S, Zhang X, Zhou Y, Zhu P, Chen S.   +29 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Background trade winds and climate sensitivity control the eastern equatorial Pacific warming pattern. [PDF]

Sci Adv
Stuivenvolt-Allen J, Fedorov AV.
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Corrigendum to "Phage tail protein methylation enabling the virus to bind to the surface of bacterial cells is vital for progeny infectivity" [Cell Insight 5 (2026) 100345]. [PDF]

Cell Insight
Fan S, Li J, Wei Y, Zhang Y, Guo X, Wu D, He ZG.   +6 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source