Results 141 to 150 of about 6,834,000 (312)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Modelling malaria environmental suitability and population exposure using the analytic hierarchy process among local government areas in Bayelsa State, Nigeria

Discover Public Health
Background Persistent malaria transmission in Africa underscores the need for spatially explicit tools that identify highly endemic areas for targeted control. Although multi-criteria decision analysis (MCDA) offers a structured approach, its application
Okpachi Christopher Abbah, Olalekan John Taiwo, James Olaoye Oyeleye, Ganiyat Eshikhena, Tamaraebi Borme, German Wisdom, Dupsy Akoma, Fayokemi Olususi, Ifeoma Ezenyi, Chioma Unogu, Kaduru Chijioke   +10 more
doaj   +1 more source

Improving service provision through change management. [PDF]

S Afr Fam Pract (2004), 2023
Naidoo M.
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Change management in higher education: A sequential mixed methods study exploring employees' perception. [PDF]

PLoS One, 2023
Ezzeddine R, Otaki F, Darwish S, AlGurg R.   +3 more
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

Change Management: From Theory to Practice. [PDF]

TechTrends, 2023
Phillips J, Klein JD.
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Successful Change Management Strategies for Improving Diabetes Care Delivery Among High-Performing Practices. [PDF]

Ann Fam Med, 2023
Peterson KA, Solberg LI, Carlin CS, Fu HN, Jacobsen R, Eder M.   +5 more
europepmc   +1 more source