Results 111 to 120 of about 3,117,785 (309)

Central Point Notice of Adopted Amendment (2015-12-17)

, 2015
10 pages.
Central Point (Or.)
core  

A Proportional Hazards Mixture Cure Model for Subgroup Analysis: Inferential Method and an Application to Colon Cancer Data

Stats
When determining subgroups with heterogeneous treatment effects in cancer clinical trials, the threshold of a variable that defines subgroups is often pre-determined by physicians based on their experience, and the optimality of the threshold is not well
Kai Liu, Yingwei Peng, Narayanaswamy Balakrishnan   +2 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Myrtle Point Notice of Adopted Amendment (2015-08-07)

, 2015
15 pages.
Myrtle Point (Or.)
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Change-point locations identified using ARMA(1,1) model displayed with the original well-log data at two different time points.

, 2018
(Left) change-point locations using ARMA(1,1) model in well-log data at time points 1 to 1000; (right) change-point locations using ARMA(1,1) model in well-log data after time point 2800.
Sarah Boyd (2443273), Farhana Sadia (6167054), Jonathan M. Keith (174258)   +2 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Cure Fraction Model for Interval Censoring with a Change Point based on a Covariate Threshold

, 2015
In this paper, a cure fraction model for interval-censored data with a change point according to a covariate threshold is proposed. Maximum likelihood estimators of the model parameters are obtained using the Expectation Maximization (EM) algorithm.
Mohd Rizam, Taweab, Fauzia, Noor Akma Ibrahim, Ibrahim, Noor Akma, Fauzia Taweab   +4 more
core   +1 more source

The influence of ocean waves on Antarctic sea-ice albedo and seasonal melting, and potential coupled physical and biological feedbacks [PDF]

The Cryosphere
Identifying the full suite of processes that drive the melting of Antarctic sea ice each summer is crucial to improving the currently-poor ability of contemporary models to accurately simulate the climatological retreat phase of the annual sea-ice cycle.
R. A. Massom, R. A. Massom, R. A. Massom, P. A. Reid, P. A. Reid, S. G. Warren, B. Light, B. Light, D. K. Perovich, L. G. Bennetts, L. G. Bennetts, P. Uotila, S. P. O'Farrell, M. H. Meylan, K. M. Meiners, K. M. Meiners, K. M. Meiners, P. Wongpan, P. Wongpan, A. D. Fraser, A. D. Fraser, A. Toffoli, G. Passerotti, G. Passerotti, P. G. Strutton, P. G. Strutton, S. M. T. Chua, S. M. T. Chua, M. Fedrigo   +28 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source