Results 121 to 130 of about 3,117,785 (309)
Journal of Mathematical and Fundamental Sciences, 2013 The observed currents in the eastern equatorial Indian Ocean and in the outflow straits of the Indonesian Throughflow (ITF) are shown to have significant intraseasonal variations and coherency during January 2004 "“ November 2006.
Iskhaq Iskandar +2 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
On-line outlier and change point detection for time series
, 2013 The detection of outliers and change points from time series has become research focus in the area of time series data mining since it can be used for fraud detection, rare event discovery, event/trend change detection, etc.
Liu F(刘芳) +3 more
core
Cartographie du changement à l'aide de nuages de points 3D [PDF]
, 2022 The presentation presents the point clouds as remote sensing data for change detection. Indeed, the earth's surface is continuously changing either rapidly or slowly depending on the event.
Kharroubi, Abderrazzaq
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Marginal Likelihood for Markov-Switching and Change-Point Garch Models [PDF]
GARCH volatility models with fixed parameters are too restrictive for long time series due to breaks in the volatility process. Flexible alternatives are Markov-switching GARCH and change-point GARCH models. They require estimation by MCMC methods due to
Arnaud Dufays +2 more
core
Change-Point Estimation and Detection for Mixture of Linear Regression Models
AxiomsThis paper studies the estimation and detection problems in the mixture of linear regression models with change point. An improved Expectation–Maximization (EM) algorithm is devised specifically for multi-classified mixture data with change points. Under
Wenzhi Zhao, Tian Cheng, Zhiming Xia
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source