Results 91 to 100 of about 920,349 (257)
Frontiers in Neuroscience, 2015 Recently there has been an increased interest in using fMRI data to study the dynamic nature of brain connectivity. In this setting, the activity in a set of regions of interest (ROIs) is often modeled using a multivariate Gaussian distribution, with a ...
Yuting eXu, Martin A Lindquist
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Online Meta-Recommendation of CUSUM Hyperparameters for Enhanced Drift Detection
SensorsWith the increasing demand for time-series analysis, driven by the proliferation of IoT devices and real-time data-driven systems, detecting change points in time series has become critical for accurate short-term prediction.
Jessica Fernandes Lopes +2 more
doaj +1 more source
Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome
Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja +8 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Wavelet-Tsallis Entropy Detection and Location of Mean Level-Shifts in Long-Memory fGn Signals
Entropy, 2015 Long-memory processes, in particular fractional Gaussian noise processes, have been applied as models for many phenomena occurring in nature. Non-stationarities, such as trends, mean level-shifts, etc., impact the accuracy of long-memory parameter ...
Julio César Ramírez-Pacheco +2 more
doaj +1 more source
Change Detection Needs Change Information: Improving Deep 3-D Point Cloud Change Detection
IEEE Transactions on Geoscience and Remote SensingThis work has been submitted to the IEEE for possible ...
de Gélis, Iris +2 more
openaire +4 more sources
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Change Point Detection in Financial Market Using Topological Data Analysis
SystemsChange points caused by extreme events in global economic markets have been widely studied in the literature. However, existing techniques to identify change points rely on subjective judgments and lack robust methodologies.
Jian Yao +4 more
doaj +1 more source