Results 91 to 100 of about 7,796,160 (295)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Time‐varying copula‐based compound flood risk assessment of extreme rainfall and high water level under a non‐stationary environment

Journal of Flood Risk Management
Quantifying flood risk depends on accurate probability estimation, which is challenging due to non‐stationarity and the combined effects of multiple factors in a changing environment.
Mingming Song, Jianyun Zhang, Yanli Liu, Cuishan Liu, Zhenxin Bao, Junliang Jin, Ruimin He, Guodong Bian, Guoqing Wang   +8 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Changing climate and rising seas: understanding the science [PDF]

, 2014
An investigation of what is causing climate change and one of its major impacts – the rising level of the sea. Introduction The level of the sea is constantly changing everywhere on Earth as tides rise and fall in predictable patterns.
Parliamentary Commissioner for the Environment
core  

Guns & roses: Comparative civil-military relations in the changing security environment

, 2019
This edited volume provides a critical and comparative discussion of the changing synergy between the military and society in the dramatically transforming global security climate, drawing on examples from the Asian, Pacific, African, Middle Eastern ...
Compel, Radomir, Ratuva, Steven, Aguilar, Sergio [UNESP]   +2 more
core   +1 more source

Kansas Environment, 2008

, 2008
No known reports between 2003 and 2007 2008 onward published biennially "The publication of the 2008 Kansas Environment report represents the return to a biennial report for the Division of Environment at the Kansas Department of Health and Environment."
Kansas. Department of Health and Environment
core   +1 more source

Temporal-spatial Evolution of Drought Characteristics at Different Grades in Yulin

Renmin Zhujiang, 2021
Under the background of climate warming and human activities,Yulin city suffers from frequent drought,which has adverse effect on the agriculture,ecological environment and social economy in this area.Although the adverse effects of drought on the Loess ...
KONG Gang, ZHANG Shanliang, WANG Lu, HUANG Shengzhi, BAI Jueying   +4 more
doaj  

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source