Results 91 to 100 of about 750,328 (309)

Learning in a changing environment [PDF]

, 2009
Multiple cue probability learning studies have typically focused on stationary environments. We present three experiments investigating learning in changing environments.
Shanks, D.R., Speekenbrink, M.
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Disaster Risk Reduction in the Built Environment in Sri Lanka- An overview [PDF]

, 2013
Natural disasters have long-term implications on sustainable development. They mainly destroy the built environment thereby hindering economic and social development, and causing environment degradation.
Amaratunga, Dilanthi, Haigh, Richard, Ginige, Kanchana   +2 more
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Time‐varying copula‐based compound flood risk assessment of extreme rainfall and high water level under a non‐stationary environment

Journal of Flood Risk Management
Quantifying flood risk depends on accurate probability estimation, which is challenging due to non‐stationarity and the combined effects of multiple factors in a changing environment.
Mingming Song, Jianyun Zhang, Yanli Liu, Cuishan Liu, Zhenxin Bao, Junliang Jin, Ruimin He, Guodong Bian, Guoqing Wang   +8 more
doaj   +1 more source

The changing roles and identities of library and information services staff [PDF]

, 2010
A review of the changing roles of library, IT and e-learning staff from 1960 to date.
Law, Derek
core  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Altered Landscape: Photographs of a Changing Environment [PDF]

, 2012
Book Review of Altered Landscape: Photographs of a Changing Environment, ed. by Ann M. Wolfe. ISBN 9780847836833.
Andrea V Cancellare
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source