Results 71 to 80 of about 597,437 (258)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

New flood characteristics and technological needs in China under a changing environment

Shui kexue jinzhan
China experiences frequent flooding due to its unique geographical and monsoon climate conditions，making it one of the most flood-prone countries in the world. This creates ongoing challenges for flood control and disaster reduction.
Jianyun ZHANG, Ruimin HE, Junliang JIN, Kang XIE, Qingfang HU   +4 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Estimation of design flood using equivalent reliability method under changing environment

Shui kexue jinzhan, 2017
The intensified impact of climate change and anthropogenic activities has changed the stationary characteristics of the hydrological extreme series, thus posing a challenge on the Traditional Hydrological Frequency Analysis (THFA) method.
LIANG Zhongmin, HU Yiming, WANG Jun, LI Binquan, YANG Jing   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Responses of hydrological drought properties and water shortage under changing environments in Dongjiang River basin

Shui kexue jinzhan, 2016
Modeling the joint distribution of hydrological drought associated with non-stationary drought properties under the effects of uncertain drought events and low flow variability is difficult.
TU Xinjun, CHEN Xiaohong, ZHAO Yong, DU Yiliang, MA Mingwei, LI Kun   +5 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Time‐varying copula‐based compound flood risk assessment of extreme rainfall and high water level under a non‐stationary environment

Journal of Flood Risk Management
Quantifying flood risk depends on accurate probability estimation, which is challenging due to non‐stationarity and the combined effects of multiple factors in a changing environment.
Mingming Song, Jianyun Zhang, Yanli Liu, Cuishan Liu, Zhenxin Bao, Junliang Jin, Ruimin He, Guodong Bian, Guoqing Wang   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source