Results 81 to 90 of about 7,796,160 (295)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
New flood characteristics and technological needs in China under a changing environment
Shui kexue jinzhanChina experiences frequent flooding due to its unique geographical and monsoon climate conditions，making it one of the most flood-prone countries in the world. This creates ongoing challenges for flood control and disaster reduction.
Jianyun ZHANG +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A Critical Review of the Literature on Structural Adjustment and the Environment
, 2003 This paper analyzes the available literature about the effects of structural adjustment programs (SAPs) on the environment and the convincing evidence for their success or failure.
Gueorguieva, Anna, Bolt, Katherine
core +1 more source
Shui kexue jinzhan, 2016 Modeling the joint distribution of hydrological drought associated with non-stationary drought properties under the effects of uncertain drought events and low flow variability is difficult.
TU Xinjun +5 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
The State of the Kansas Environment, 2010
, 2010 No known reports between 2003 and 2007 2008 onward published biennially The publication of the 2008 Kansas Environment report represents the return to a biennial report for the Division of Environment at the Kansas Department of Health and Environment." -
Kansas. Department of Health and Environment
core +1 more source
Estimation of design flood using equivalent reliability method under changing environment
Shui kexue jinzhan, 2017 The intensified impact of climate change and anthropogenic activities has changed the stationary characteristics of the hydrological extreme series, thus posing a challenge on the Traditional Hydrological Frequency Analysis (THFA) method.
LIANG Zhongmin +4 more
doaj +1 more source