Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Correction: An SIRS model with nonmonotone incidence and saturated treatment in a changing environment. [PDF]
J Math Biol, 2023 Pan Q, Huang J, Wang H.
europepmc +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Working Effectively Within a Changing Organisational Environment
JANZSSA, 2002 During recent years there have been many changes in organisations. The changes that have impacted on the structural framework of organisations include the size of the organisation, the core business of the organisation, the goals and strategies, the ...
Maureen Burke, Malcolm MacKenzie
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Salpa genome and developmental transcriptome analyses reveal molecular flexibility enabling reproductive success in a rapidly changing environment. [PDF]
Sci Rep, 2023 Castellano KR +3 more
europepmc +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
An SIRS model with nonmonotone incidence and saturated treatment in a changing environment. [PDF]
J Math Biol, 2022 Pan Q, Huang J, Wang H.
europepmc +1 more source
THE ROLE OF AGRICULTURAL ECONOMICS IN A CHANGING ENVIRONMENT [PDF]
Environmental Economics and Policy,
Ewing, John A.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Oxidation and fragmentation of plastics in a changing environment; from UV-radiation to biological degradation. [PDF]
Sci Total Environ, 2022 Andrady AL +7 more
europepmc +1 more source