Results 141 to 150 of about 750,328 (309)

Integrated Care in the Context of a Changing Environment - does it Matter? [PDF]

Int J Integr Care, 2022
Stein KV.
europepmc   +1 more source

Ecosystem services and livelihoods – vulnerability and adaptation to a changing climate. VACCIA synthesis report [PDF]

, 2011
This report is a summary of results from the project Vulnerability Assessment of Ecosystem Services for Climate Change Impacts and Adaptation (VACCIA), funded by the European Union’s LIFE+ programme.

core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

A genetic study of immunity in depression and interactions with childhood maltreatment

Translational Psychiatry
Genetic and environmental factors contribute to depression. Among the latter, early life adversity and immune dysregulation have been consistently linked with depression.
Marisol Herrera-Rivero, Daniel L. McCartney, Heather C. Whalley, Klaus Berger, Andrew M. McIntosh, Bernhard T. Baune   +5 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

The response of a metapopulation to a changing environment. [PDF]

Philos Trans R Soc Lond B Biol Sci, 2022
Barton N, Olusanya O.
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

How Does Changing Environment Influence Plant Seed Movements as Populations of Dispersal Vectors Decline? [PDF]

Plants (Basel), 2023
Hernandez JO, Naeem M, Zaman W.
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Analysis of Evolutionary Characteristics of Highest Water Levels in Pearl River Guangzhou Reach under Changing Environments

Renmin Zhujiang
The evolution characteristics of the highest water levels in the Pearl River are of great significance for the planning and design of flood control works in Guangzhou.
WANG Jin, LIANG Yingshan, LIN Kairong
doaj