Results 151 to 160 of about 3,756,943 (255)

Biodiversity conservation in a changing environment beyond 2020. [PDF]

Sci Adv, 2021
Lu Y, Bullock JM.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Neuropeptide dynamics coordinate layered plasticity mechanisms adapting <i>Drosophila</i> circadian behavior to changing environment. [PDF]

Sci Adv
Chatterjee A, De J, Martin B, Chélot E, Zhong P, Rouyer F.   +5 more
europepmc   +1 more source

Editorial: Tropical Montane Forests in a Changing Environment. [PDF]

Front Plant Sci, 2021
Salinas N, Cosio EG, Silman M, Meir P, Nottingham AT, Roman-Cuesta RM, Malhi Y.   +6 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Oral Health and Climate Change: Working Toward Adaptive Strategies to the Changing Environment. [PDF]

J Int Soc Prev Community Dent
Shrivastava SR, Bobhate PS, Kukde M.
europepmc   +1 more source

Variation in blubber cortisol levels in a recovering humpback whale population inhabiting a rapidly changing environment. [PDF]

Sci Rep, 2022
Pallin LJ, Botero-Acosta N, Steel D, Baker CS, Casey C, Costa DP, Goldbogen JA, Johnston DW, Kellar NM, Modest M, Nichols R, Roberts D, Roberts M, Savenko O, Friedlaender AS.   +14 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Azov-type spits: long-term monitoring of morphodynamics and vegetation in response to changing environment. [PDF]

PeerJ
Tyshchenko O, Tyshchenko V, Boychenko S, Tarieiev A, Tkachenko V.   +4 more
europepmc   +1 more source

The perception and response of T cells to a changing environment are based on the law of initial value. [PDF]

Sci Signal, 2022
Huseby ES, Teixeiro E.
europepmc   +1 more source