Results 71 to 80 of about 3,756,943 (255)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Observed trends in the magnitude and persistence of monthly temperature variability

open access: yesScientific Reports, 2017
Climate variability is critically important for nature and society, especially if it increases in amplitude and/or fluctuations become more persistent.
Timothy M. Lenton   +3 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Analysis of Evolutionary Characteristics of Highest Water Levels in Pearl River Guangzhou Reach under Changing Environments

open access: yesRenmin Zhujiang
The evolution characteristics of the highest water levels in the Pearl River are of great significance for the planning and design of flood control works in Guangzhou.
WANG Jin, LIANG Yingshan, LIN Kairong
doaj  

Changing Tendencies in the Commercial Society with Limited Liability Rafeba [PDF]

open access: yesOvidius University Annals: Economic Sciences Series, 2018
In my present paper I have proposed to present a tendency for change in an organization withthe profile of guarding the objectives, goods, values and protection of the persons, but also with themounting, calibration, configuration of the surveillance ...
Vasciuc (Săndulescu) Cristina Gabriela
doaj  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A Case Study of Assimilating Lightning-Proxy Relative Humidity with WRF-3DVAR

open access: yesAtmosphere, 2017
Lightning network data, considered as a useful supplement to radar observations, are a good indicator of severe convection, and has high temporal and spatial resolution.
Ying Wang   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The Changing Legal Environment and ICWA in Alaska: A Regional Study [PDF]

open access: yes, 2001
By 1974, according to the Association of American Indian Affairs, approximately 25 to 35 percent of all Indian children were separated from their families and placed in foster homes, adoptive homes, or institutions.The Indian Child Welfare Act (ICWA) was
Brown, Caroline, Rieger, Lisa
core  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

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