Results 51 to 60 of about 4,557,905 (293)

Post-wildfire sediment source and transport modeling, empirical observations, and applied mitigation: an Arizona, USA, case study [PDF]

Natural Hazards and Earth System Sciences
Post-wildfire floods are receiving greater attention as wildland–urban interfaces become more common and catastrophic wildfires have increased in frequency.
E. R. Schenk, A. Wood, A. Haden, G. Baca, J. Fleishman, J. Loverich   +5 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Relationship Between Cannabis Dispensary Density, Proximity, and Attitudes Toward Medical Cannabis: A Cross‐Sectional Study

Health Science Reports
Background and Aims Public attitudes toward medicinal cannabis (MC) remain mixed, particularly in areas with legal access to recreational cannabis (RC).
Thomas A. Clobes, Sean Himebaugh, Sandra Aguilar Gamez, Mariza Torres   +3 more
doaj   +1 more source

Channel spaser

, 2011
We show that net amplification of surface plasmons is achieved in channel in a metal plate due to nonradiative excitation by quantum dots. This makes possible lossless plasmon transmission lines in the channel as well as the amplification and generation ...
A. A. Lisyansky, A. A. Pukhov, A. P. Vinogradov, A. V. Dorofeenko, E. D. Palik, H. Raether, I. A. Nechepurenko, L. D. Landau, L. Novotny, M. A. Noginov, M. O. Scully, R. Pantell, S. V. Gaponenko   +12 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Sodium channels [PDF]

Brain and Neuroscience Advances, 2018
In 2000, with the completion of the human genome project, nine related channels were found to comprise the complete voltage-gated sodium gene family and they were renamed NaV1.1–NaV1.9. This millennial event reflected the extraordinary impact of molecular genetics on our understanding of electrical signalling in the nervous system.
Wood, JN, Iseppon, F
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry

eLife
The serotonin-gated ion channel (5-HT3R) mediates excitatory neuronal communication in the gut and the brain. It is the target for setrons, a class of competitive antagonists widely used as antiemetics, and is involved in several neurological diseases ...
Laurie Peverini, Sophie Shi, Karima Medjebeur, Pierre-Jean Corringer   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Hot Channel

, 2007
This paper studies on-chip communication with non-ideal heat sinks. A channel model is proposed where the variance of the additive noise depends on the weighted sum of the past channel input powers.
Koch, Tobias, Lapidoth, Amos, Sotiriadis, Paul P.   +2 more
core   +1 more source