Results 61 to 70 of about 3,122,392 (352)

Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry

eLife
The serotonin-gated ion channel (5-HT3R) mediates excitatory neuronal communication in the gut and the brain. It is the target for setrons, a class of competitive antagonists widely used as antiemetics, and is involved in several neurological diseases ...
Laurie Peverini, Sophie Shi, Karima Medjebeur, Pierre-Jean Corringer   +3 more
doaj   +1 more source

Humpback whale migrations to Antarctic summer foraging grounds through the southwest Pacific Ocean

Scientific Reports, 2018
Humpback whale (Megaptera novaeangliae) populations typically undertake seasonal migrations, spending winters in low latitude breeding grounds and summers foraging in high latitude feeding grounds.
V. Andrews-Goff, S. Bestley, N. J. Gales, S. M. Laverick, D. Paton, A. M. Polanowski, N. T. Schmitt, M. C. Double   +7 more
doaj   +1 more source

Impact of Zeolite to Maintain Water Quality and Increasing the Growth of Mono-sex Male Nile Tilapia Cultured in Concrete Ponds [PDF]

Journal of Soil Sciences and Agricultural Engineering
The expansion of intensiveaquaculture to decrease the gap between fish productivity and consumption negatively affects the water quality and fish productivity. Therefore, the current research aims to use zeolite to maintain water quality while increasing
Y. Ali, M. Felafel
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Post-wildfire sediment source and transport modeling, empirical observations, and applied mitigation: an Arizona, USA, case study [PDF]

Natural Hazards and Earth System Sciences
Post-wildfire floods are receiving greater attention as wildland–urban interfaces become more common and catastrophic wildfires have increased in frequency.
E. R. Schenk, A. Wood, A. Haden, G. Baca, J. Fleishman, J. Loverich   +5 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Channel 40 news segment on E. Coli rapid detection method (April 1998)

, 1998
This is a short Channel 40 news segment on Dr. Chun-Kwun Wun and Dr. Frank J. Torre development of a E. Coli Rapid Detection method. The segment is about two minutes and 20 seconds long. The segment was digitized from a VHS tape which over the years seem
ABC Channel 40;
core  

Assessing the backwater rise of floating barriers with racks for various blockages in open channels

Journal of Engineering and Applied Science
One major risk in the stream is thought to be debris. The general effects of debris spreading have a detrimental effect on water infrastructure and water activities.
Mahmoud Zayed, Mahmoud Saleh
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source