Results 61 to 70 of about 4,557,905 (293)
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Single-channel recordings from cultured human retinal pigment epithelial cells. [PDF]
, 1988 We have applied patch-clamp techniques to on-cell and excised-membrane patches from human retinal pigment epithelial cells in tissue culture. Single-channel currents from at least four ion channel types were observed: three or more potassium-selective ...
Fain, GL, Fox, JA, Pfeffer, BA
core
Rate-Equivocation Optimal Spatially Coupled LDPC Codes for the BEC Wiretap Channel
, 2011 We consider transmission over a wiretap channel where both the main channel and the wiretapper's channel are Binary Erasure Channels (BEC). We use convolutional LDPC ensembles based on the coset encoding scheme.
Andersson, Mattias +3 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Assessing the backwater rise of floating barriers with racks for various blockages in open channels
Journal of Engineering and Applied ScienceOne major risk in the stream is thought to be debris. The general effects of debris spreading have a detrimental effect on water infrastructure and water activities.
Mahmoud Zayed, Mahmoud Saleh
doaj +1 more source
Water Science, 2018 Aquatic weeds management and estimation of water losses from evapotranspiration must be taken into consideration in order to reduce water losses. The objective of this research is estimating the water losses through evapotranspiration of aquatic weeds in
Yasser Mahmoud Ali +1 more
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Understanding the key drivers of and technology related issues associated with going multi-channel [PDF]
, 2012 A multi-channel retail strategy is viewed by many academics and practitioners to be the success model for most retailers. Yet, while there are many drivers of, and advantages related to, using multiple channels to sell products and services to customers ...
Foster, C, Lewis, J, Whysall, P
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
CellsPacemaking activity in substantia nigra dopaminergic neurons is generated by the coordinated activity of a variety of distinct somatodendritic voltage- and calcium-gated ion channels. We investigated whether these functional interactions could arise from
Maya Belghazi +6 more
doaj +1 more source