Results 51 to 60 of about 4,606,414 (240)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
High y+ Shear-Stress Turbulence Implementation for High Flux Isotope Reactor Narrow Channel Flows
FluidsThe research objective of this work was to improve the engineering predictions of the turbulence characteristics of flows in curved narrow channels. Such channel flows are commonly encountered in nuclear research and test reactors, with one of them being
Emilian Popov +2 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Effect of corner shape on pressure loss and heat transfer of turbulent channel flow with T-junction
Nihon Kikai Gakkai ronbunshu, 2014 An experimental study is performed for dividing turbulent channel flow in 90 degree T-junction with sharp, inclined and rounded corners. Experiment is conducted for flow rate ratios of 0.2, 0.4, 0.6 and 0.8 (ratio between the flow rates in the branch and
Masatoshi SANO, Yuki KOIDE
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Prandtl number effect on near wall temperature profile in high-Reynolds number channel flows
Nihon Kikai Gakkai ronbunshu, 2014 Prandtl number (Pr) effects on characteristics of the thermal boundary layer were investigated by means of Direct Numerical Simulations (DNS) in high-Reynolds number turbulent channel flows. The molecular Pr conditions were changed from 0.71 to 25.0, and
Shogo SARUWATARI, Yoshinobu YAMAMOTO
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
The Journal of Engineering, 2018 The aero-engine to be cleaned online can significantly improve compressor performance and increase maintenance intervals, but the cleaning online cannot achieve the anticipated effects due to the lack of cognisance of the internal multiphase flow field ...
Liwen Wang +4 more
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Low- and High-Drag Intermittencies in Turbulent Channel Flows
Entropy, 2020 Recent direct numerical simulations (DNS) and experiments in turbulent channel flow have found intermittent low- and high-drag events in Newtonian fluid flows, at Reτ=uτh/ν between 70 and 100, where uτ, h and ν are the friction velocity, channel half ...
Rishav Agrawal +6 more
doaj +1 more source