Results 71 to 80 of about 1,383,477 (261)

Development of a neurophysiological sensory gating model in the rat to aid in the preclinical identification of possible treatments of sensory flooding in schizophrenia [PDF]

, 2013
Objective: It has been widely hypothesized that a failure to properly filter, or ‘gate’, incoming auditory information occurs in schizophrenic patients. This can be observed in a reduced event-related potential response to the second of a pair of clicks,
Bloomfield, Andrew
core   +2 more sources

Structure-based membrane dome mechanism for Piezo mechanosensitivity

eLife, 2017
Mechanosensitive ion channels convert external mechanical stimuli into electrochemical signals for critical processes including touch sensation, balance, and cardiovascular regulation. The best understood mechanosensitive channel, MscL, opens a wide pore,
Yusong R Guo, Roderick MacKinnon
doaj   +1 more source

Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions. [PDF]

PLoS Biology, 2013
Pentameric ligand-gated ion channels (pLGICs) are neurotransmitter-activated receptors that mediate fast synaptic transmission. In pLGICs, binding of agonist to the extracellular domain triggers a structural rearrangement that leads to the opening of an ...
Cosma D Dellisanti, Borna Ghosh, Susan M Hanson, James M Raspanti, Valerie A Grant, Gaoussou M Diarra, Abby M Schuh, Kenneth Satyshur, Candice S Klug, Cynthia Czajkowski   +9 more
doaj   +1 more source

Unsupervised Machine Learning Identifies Shared Biomechanical and Clinical Variation in Individuals with Knee Osteoarthritis and High BMI: A Secondary Analysis of the IDEA Trial

Arthritis Care &Research, Accepted Article.
Objective High body mass index (BMI≥27 kg/m2) and aberrant gait biomechanics are primary risk factors for knee osteoarthritis (KOA), yet the specific loading patterns linked to clinical disease features remain unclear. Unsupervised machine learning (ML) was used to identify vertical ground reaction force (vGRF) waveform modes of variation and ...
Ashley N. Buck, J. Elyse Borgert, Hyeon Lee, Liubov Arbeeva, Yvonne M. Golightly, Richard F. Loeser, Leigh F. Callahan, Stephen P. Messier, Brian Pietrosimone, Amanda E. Nelson, James S. Marron   +10 more
wiley   +1 more source

The activation mechanism of alpha 1 homomeric glycine receptors [PDF]

, 2004
The glycine receptor mediates fast synaptic inhibition in the spinal cord and brainstem. Its activation mechanism is not known, despite the physiological importance of this receptor and the fact that it can serve as a prototype for other homopentameric ...
Sivilotti, LG, Colquhoun, D, Groot-Kormelink, PJ, Beato, M   +3 more
core  

An Unorthodox Mechanism Underlying Voltage Sensitivity of TRPV1 Ion Channel

Advanced Science, 2020
While the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) channel is a polymodal nociceptor for heat, capsaicin, and protons, the channel's responses to each of these stimuli are profoundly regulated by membrane potential, damping or ...
Fan Yang, Lizhen Xu, Bo Hyun Lee, Xian Xiao, Vladimir Yarov‐Yarovoy, Jie Zheng   +5 more
doaj   +1 more source

Materials‐Driven Additive Manufacturing for Electrical Machines: Qualification‐Oriented Design Beyond Geometric Freedom

Advanced Engineering Materials, EarlyView.
This perspective reframes additive manufacturing for electrical machines as a qualification‐limited materials and architecture design problem. It links process–structure–property–performance relationships to magnetic, conducting, dielectric, and thermal property windows, highlighting where AM can enable segmented magnetic circuits, permanent magnet ...
Dénes Fodor, Loránd Szabó
wiley   +1 more source

All‐in‐One Analog AI Hardware: On‐Chip Training and Inference with Conductive‐Metal‐Oxide/HfOx ReRAM Devices

Advanced Functional Materials, EarlyView.
An all‐in‐one analog AI accelerator is presented, enabling on‐chip training, weight retention, and long‐term inference acceleration. It leverages a BEOL‐integrated CMO/HfOx ReRAM array with low‐voltage operation (<1.5 V), multi‐bit capability over 32 states, low programming noise (10 nS), and near‐ideal weight transfer.
Donato Francesco Falcone, Victoria Clerico, Wooseok Choi, Tommaso Stecconi, Folkert Horst, Laura Bégon‐Lours, Matteo Galetta, Antonio La Porta, Nikhil Garg, Fabien Alibart, Bert Jan Offrein, Valeria Bragaglia   +11 more
wiley   +1 more source

Structural titration of receptor ion channel GLIC gating by HS-AFM

, 2018
Comment in Direct visualization of ion-channel gating in a native environment. [Proc Natl Acad Sci U S A. 2018]International audienceGloeobacter violaceus ligand-gated ion channel (GLIC), a proton-gated, cation-selective channel, is a prokaryotic ...
Scheuring, Simon, Ruan, Yi, Kao, Kevin, Marchesi, Arin, Hite, Richard, Corringer, Pierre-Jean, Lefebvre, Solène, Marchesi A., Ruan Y., Kao K., Corringer P. -J., Lefebvre S., Hite R. K., Scheuring S.   +13 more
core   +1 more source

Gating charge displacement in a monomeric voltage-gated proton (Hv1) channel [PDF]

, 2018
© 2018 National Academy of Sciences. All Rights Reserved. The voltage-gated proton (Hv1) channel, a voltage sensor and a conductive pore contained in one structural module, plays important roles in many physiological processes.
Neely, Alan, Gonzalez, Carlos, Latorre, Ramón, Larsson, H. Peter, Carmona, Emerson M., Peter Larsson, H., Alvarez, Osvaldo, Carmona, Emerson M   +7 more
core   +1 more source