Results 81 to 90 of about 807,233 (265)

Study on Performance Simulation of Vascular-like Flow Channel Model Based on TPMS Structure. [PDF]

Biomimetics (Basel), 2023
Shi J, Wei F, Chouraki B, Sun X, Wei J, Zhu L.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Path loss modeling and performance evaluation of double IRSs-aided wireless communication systems based on spatial scattering channel model. [PDF]

Sci Rep, 2023
Wang J, Ni H.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Transmit Power Optimization for Intelligent Reflecting Surface-Assisted Coal Mine Wireless Communication Systems

IoT
The adverse propagation environment in underground coal mine tunnels caused by enclosed spaces, rough surfaces, and dense scatterers severely degrades reliable wireless signal transmission, which further impedes the deployment of IoT applications such as
Yang Liu, Xiaoyue Li, Bin Wang, Yanhong Xu   +3 more
doaj   +1 more source

Minimizing Area-Specific Resistance of Electrochemical Hydrogen Compressor under Various Operating Conditions Using Unsteady 3D Single-Channel Model. [PDF]

Membranes (Basel), 2023
Gong M, Jin C, Na Y.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Optical Camera-Based Integrated Sensing and Communication for V2X Applications: Model and Optimization

Sensors
An optical camera-based integrated sensing and communication (OC-ISAC) system model is proposed to address the intrinsic requirements of vehicular-to-everything (V2X) applications in complex outdoor environments.
Ke Dong, Wenying Cao, Mingjun Wang
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

A Novel Stochastic Channel Model for WPAN Short-Range Scenarios Based on 3GPP Framework and LoS Multipath Measurements at 105 GHz

IEEE Open Journal of Vehicular Technology
This paper presents a novel stochastic channel model (SCM) for wireless personal area network (WPAN) short-range scenarios based on the third-generation partnership project (3GPP) framework and line-of-sight (LoS) multipath measurements at 105 GHz with a
Mihiro Hashimoto, Yusuke Koda, Norichika Ohmi, Hiroaki Endo, Hiroshi Harada   +4 more
doaj   +1 more source