Results 101 to 110 of about 26,654,237 (305)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Attention-Guided Wireless Channel Modeling and Generating

Applied Sciences
Due to the fast advancement in wireless communication technology, the demand for the modeling and generating of wireless channels is increasing. Deep learning technology is gradually applied in the wireless communication field, and the Generative ...
Yawen He, Nan Xu, Li Cheng, Haiwen Yuan
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A Universal Attenuation Model of Terahertz Wave in Space-Air-Ground Channel Medium

IEEE Open Journal of the Communications Society
Providing continuous bandwidth over several tens of GHz, the Terahertz (THz) band (0.1-10 THz) supports space-air-ground integrated network (SAGIN) in 6G and beyond wireless networks.
Zhirong Yang, Weijun Gao, Chong Han
doaj   +1 more source

Cooperative In-Vivo Nano-Network Communication at Terahertz Frequencies

IEEE Access, 2017
Nano-devices have great potential to play a vital role in future medical diagnostics and treatment technologies because of its non-invasive nature and ability to reach delicate body sites easily as compared with conventional devices.
Qammer H. Abbasi, Ali Arshad Nasir, Ke Yang, Khalid A. Qaraqe, Akram Alomainy   +4 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Machine Learning-Based Method for LOS/NLOS Identification in V2V Environment

IEEE Access
Accurate identification of line-of-sight (LOS) and non-line-of-sight (NLOS) conditions is a critical challenge in wireless communication, particularly the vehicle-to-vehicle (V2V) channels, owing to the high dynamics inherent to V2V environments.
Yousra Chakkour, Vicent Miquel Rodrigo Penarrocha, Lorenzo Rubio, Herman Fernandez, Juan Reig   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Comprehensive Analysis of CNN-Based Models for SNR Estimation

IEEE Access
Deep learning (DL) models offer a promising solution for Signal-to-Noise Ratio (SNR) estimation in wireless communication systems. Recently, regression-based DL approaches have been explored to overcome the limitations of classification-based methods ...
Abdullah Al Mahbub, Ijaz Ahmad, Seokjoo Shin   +2 more
doaj   +1 more source