Results 31 to 40 of about 18,132 (269)

Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels

Channels, 2023
Recent years have seen an outpouring of atomic or near atomic resolution structures of cyclic nucleotide-gated (CNG) channels, captured in closed, transition, pre-open, partially open, and fully open states.
Zhengshan Hu, Jian Yang
semanticscholar   +1 more source

Sudden cardiac death in young athletes: Literature review of molecular basis [PDF]

, 2020
Intense athletic training and competition can rarely result in sudden cardiac death (SCD). Despite the introduction of pre-participation cardiovascular screening, especially among young competitive athletes, sport-related SCD remains a debated issue ...
Barbara Lombardo, Bruno Mirra, Cristina Mazzaccara, Ferdinando Barretta, Giulia Frisso, Olga Scudiero   +5 more
core   +1 more source

Restoring the Function of Thalamocortical Circuit Through Correcting Thalamic Kv3.2 Channelopathy Normalizes Fear Extinction Impairments in a PTSD Mouse Model

Advancement of science, 2023
Impaired extinction of fear memory is one of the most common symptoms in post‐traumatic stress disorder (PTSD), with limited therapeutic strategies due to the poor understanding of its underlying neural substrates.
Haoxiang Xiao, Kaiwen Xi, Kaifang Wang, Yongsheng Zhou, Baowen Dong, Jinyi Xie, Yuqiao Xie, Haifeng Zhang, Guaiguai Ma, Wenting Wang, Dayun Feng, Baolin Guo, Shengxi Wu   +12 more
semanticscholar   +1 more source

Is the Sex Difference a Clue to the Pathomechanism of Dry Eye Disease? Watch out for the NGF-TrkA-Piezo2 Signaling Axis and the Piezo2 Channelopathy

Journal of Molecular Neuroscience, 2022
Dry eye disease (DED) is a multifactorial disorder with recognized pathology, but not entirely known pathomechanism. It is suggested to represent a continuum with neuropathic corneal pain with the paradox that DED is a pain-free disease in most cases ...
B. Sonkodi, M. Resch, Tibor Hortobágyi
semanticscholar   +1 more source

Evaluation of subcutaneous implantable cardioverter-defibrillator performance in patients with ion channelopathies from the EFFORTLESS cohort and comparison with a meta-analysis of transvenous ICD outcomes

Heart Rhythm O2, 2020
Background: The subcutaneous implantable cardioverter-defibrillator (S-ICD) is an alternative to conventional transvenous ICD (TV-ICD) therapy to reduce lead complications.
Pier D. Lambiase, MBChB, PhD, FHRS, Lars Eckardt, MD, Dominic A. Theuns, PhD, Timothy R. Betts, MD, Andreas L. Kyriacou, MBChB, FRCP, PhD, CCDS, Elizabeth Duffy, MS, Reinoud Knops, MD, PhD, CCDS   +6 more
doaj   +1 more source

Neuronal mechanism of a BK channelopathy in absence epilepsy and dyskinesia

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance BK channelopathy has been increasingly implicated in diverse neurological disorders, including epilepsy and movement, cognitive, and neurodevelopmental disorders. However, precision medicine to treat BK channelopathy is lacking.
Ping Dong, Yang Zhang, Arsen S Hunanyan, M. Mikati, J. Cui, Huanghe Yang   +5 more
semanticscholar   +1 more source

An emerging spectrum of variants and clinical features in KCNMA1-linked channelopathy

Channels, 2021
KCNMA1-linked channelopathy is an emerging neurological disorder characterized by heterogeneous and overlapping combinations of movement disorder, seizure, developmental delay, and intellectual disability.
Jacob P Miller, Hans J. Moldenhauer, Sotirios Keros, A. Meredith   +3 more
semanticscholar   +1 more source

Structural Heart Alterations in Brugada Syndrome: Is it Really a Channelopathy? A Systematic Review

Journal of Clinical Medicine, 2022
Brugada syndrome (BrS) is classified as an inherited cardiac channelopathy attributed to dysfunctional ion channels and/or associated proteins in cardiomyocytes rather than to structural heart alterations.
A. Oliva, S. Grassi, V. Pinchi, F. Cazzato, M. Coll, M. Alcalde, M. Vallverdú-Prats, Alexandra Pérez-Serra, Estefanía Martínez-Barrios, S. César, Anna Iglesias, J. Cruzalegui, Clara Magdalena Martínez Hernández, V. Fiol, E. Arbelo, N. Díez-Escuté, V. Arena, J. Brugada, G. Sarquella-Brugada, R. Brugada, Ó. Campuzano   +20 more
semanticscholar   +1 more source

1029 genomes of self-declared healthy individuals from India reveal prevalent and clinically relevant cardiac ion channelopathy variants

Human Genomics, 2022
Background The prevalence and genetic spectrum of cardiac channelopathies exhibit population-specific differences. We aimed to understand the spectrum of cardiac channelopathy-associated variations in India, which is characterised by a genetically ...
Anjali Bajaj, Vigneshwar Senthivel, Rahul Bhoyar, Abhinav Jain, Mohamed Imran, Mercy Rophina, Mohit Kumar Divakar, Bani Jolly, Ankit Verma, Anushree Mishra, Disha Sharma, Siddharthan Deepti, Gautam Sharma, Raghav Bansal, Rakesh Yadav, Vinod Scaria, Nitish Naik, Sridhar Sivasubbu   +17 more
doaj   +1 more source

Shank3‐deficient thalamocortical neurons show HCN channelopathy and alterations in intrinsic electrical properties

Journal of Physiology, 2018
Vinay Kumar Idikuda, Nikhil Shah, Qinglian Liu   +2 more
exaly   +2 more sources