Results 1 to 10 of about 18,263 (235)
Communications Biology, 2021 Dreier et al. reports that the anion channelrhodopsin GtACR1 does not undergo a syn-cycle (light adapted ground state) and thus has a more efficient channel behaviour than CrChR2.
Max-Aylmer Dreier +8 more
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Communications Biology, 2021 Tashiro et al. describe a new channelrhodopsin variant from a terrestrial algal species and the role of the C-terminal domain in regulatory function. This far-blue-shifted channelrhodopsin may contribute to optogenetic tool research in the future.
Rintaro Tashiro +6 more
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Atomistic Insight into the Role of Threonine 127 in the Functional Mechanism of Channelrhodopsin-2 [PDF]
Applied Sciences, 2019 Channelrhodopsins (ChRs) belong to the unique class of light-gated ion channels. The structure of channelrhodopsin-2 from Chlamydomonas reinhardtii (CrChR2) has been resolved, but the mechanistic link between light-induced isomerization of the ...
David Ehrenberg +9 more
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eLife, 2021 Channelrhodopsins (ChRs) are microbial light-gated ion channels utilized in optogenetics to control neural activity with light . Light absorption causes retinal chromophore isomerization and subsequent protein conformational changes visualized as ...
Kazumasa Oda +47 more
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Cryo-EM structures of the channelrhodopsin ChRmine in lipid nanodiscs [PDF]
Nature Communications, 2021 Microbial channelrhodopsins are light-gated ion channels widely used for optogenetic manipulation of neuronal activity. ChRmine is a bacteriorhodopsin-like cation channelrhodopsin (BCCR) more closely related to ion pump rhodopsins than other ...
Kyle Tucker +3 more
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A new method for finding the minimum free energy pathway of ions and small molecule transportation through protein based on 3D-RISM theory and the string method [PDF]
Chem. Phys. Lett. 699 (2018) 22-27, 2017 A new method for finding the minimum free energy pathway (MFEP) of ions and small molecule transportation through a protein based on the three-dimensional reference interaction site model (3D-RISM) theory combined with the string method has been proposed.
Yoshida, Norio
arxiv +3 more sources
Frontiers in Aging Neuroscience, 2020 Brains depend on blood flow for the delivery of oxygen and nutrients essential for proper neuronal and synaptic functioning. French physiologist Rouget was the first to describe pericytes in 1873 as regularly arranged longitudinal amoeboid cells on ...
Amy R. Nelson +5 more
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Channelrhodopsins with distinct chromophores and binding patterns [PDF]
Nature CommunicationsChannelrhodopsins are popular optogenetic tools in neuroscience, but remain poorly understood mechanistically. Here we report the cryo-EM structures of channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii and H.
Yuanyue Shan +5 more
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The Channel Capacity of Channelrhodopsin and Other Intensity-Driven Signal Transduction Receptors [PDF]
arXiv, 2018 Biological systems transduce signals from their surroundings through a myriad of pathways. In this paper, we describe signal transduction as a communication system: the signal transduction receptor acts as the receiver in this system, and can be modeled as a finite-state Markov chain with transition rates governed by the input signal.
Andrew W. Eckford, Peter Thomas
arxiv +3 more sources
Molecules, 2020 Channelrhodopsins (ChR) are light-gated ion-channels heavily used in optogenetics. Upon light excitation an ultrafast all-trans to 13-cis isomerization of the retinal chromophore takes place.
Till Stensitzki +4 more
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