Results 91 to 100 of about 17,118 (247)

Red‐shifted channelrhodopsin stimulation restores light responses in blind mice, macaque retina, and human retina

EMBO Molecular Medicine, 2016
Targeting the photosensitive ion channel channelrhodopsin‐2 (ChR2) to the retinal circuitry downstream of photoreceptors holds promise in treating vision loss caused by retinal degeneration. However, the high intensity of blue light necessary to activate
Abhishek Sengupta, Antoine Chaffiol, Emilie Macé, Romain Caplette, Mélissa Desrosiers, Maruša Lampič, Valérie Forster, Olivier Marre, John Y Lin, José‐Alain Sahel, Serge Picaud, Deniz Dalkara, Jens Duebel   +12 more
doaj   +1 more source

Computational Modeling of Channelrhodopsin-2 Photocurrent Characteristics in Relation to Neural Signaling

, 2013
Channelrhodopsins-2 (ChR2) are a class of light sensitive proteins that offer the ability to use light stimulation to regulate neural activity with millisecond precision.
Khargonekar, Pramod P., Shivakeshavan, R. G., Stefanescu, Roxana A., Talathi, Sachin S.   +3 more
core   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Optogenetic Evocation of Field Inhibitory Postsynaptic Potentials in Hippocampal Slices: A Simple and Reliable Approach for Studying Pharmacological Effects on GABAA and GABAB Receptor-Mediated Neurotransmission

Frontiers in Cellular Neuroscience, 2014
The GABAergic system is the main source of inhibition in the mammalian brain. Consequently, much effort is still made to develop new modulators of GABAergic synaptic transmission.
Julien eDine, Claudia eKühne, Jan M Deussing, Matthias eEder   +3 more
doaj   +1 more source

Optogenetics in primates: monkey see monkey look [PDF]

, 2011
Optogenetics has emerged as a powerful tool for studying the neural basis of simple behaviors in rodents and small animals. In the primate model, however, optogenetics has had limited utility because optical methods have not been able to drive behavior ...
Gregory Horwitz, Mehrdad Jazayeri, Zachary Lindbloom-Brown   +2 more
core   +1 more source

An inhibitory pull-push circuit in frontal cortex. [PDF]

, 2017
Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons.
AA Zekveld, CK Pfeffer, CM Niell, D Huber, Dario L Ringach, DS Greenberg, Elaine Tring, HJ Pi, I Ozden, JJ Letzkus, Joshua T Trachtenberg, JS Anderson, L Petreanu, M Vinck, MJ McGinley, MM Karnani, Pablo Garcia-Junco-Clemente, PJ Mineault, PO Polack, RB Ebitz, RJ Douglas, S Lee, SL Smith, Taruna Ikrar, TW Chen, Xiangmin Xu, Y Fu   +26 more
core   +1 more source

Models of cardiomyocyte–non‐myocyte electrical interactions

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiomyocyte–non‐myocyte (CM–NM) electrotonic coupling. Left: conceptual contact‐based interactions between CM and other NM via connexin (Cx) proteins. Three basic scenarios are proposed: (i) ‘zero‐sided coupling’ where there are no electrical connections between CM and NM, (ii) ‘single‐sided coupling’ where NM are connected to ...
Ana Simon‐Chica, Axel Loewe, Peter Kohl   +2 more
wiley   +1 more source

Channelrhodopsins with distinct chromophores and binding patterns

Nature Communications
Channelrhodopsins are popular optogenetic tools in neuroscience, but remain poorly understood mechanistically. Here we report the cryo-EM structures of channelrhodopsin-2 (ChR2) from Chlamydomonas reinhardtii and H.
Yuanyue Shan, Liping Zhao, Meiyu Chen, Xiao Li, Mingfeng Zhang, Duanqing Pei   +5 more
doaj   +1 more source

Control of voluntary and optogenetically perturbed locomotion by spike rate and timing of neurons of the mouse cerebellar nuclei

eLife, 2018
Neurons of the cerebellar nuclei (CbN), which generate cerebellar output, are inhibited by Purkinje cells. With extracellular recordings during voluntary locomotion in head-fixed mice, we tested how the rate and coherence of inhibition influence CbN cell
Rashmi Sarnaik, Indira M Raman
doaj   +1 more source

All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins [PDF]

, 2013
All-optical electrophysiology—spatially resolved simultaneous optical perturbation and measurement of membrane voltage—would open new vistas in neuroscience research.
Boulting, Gabriella L, Boyden, Edward, Campbell, Robert E, Cho, Yongku, Cohen, Adam E, Farhi, Samouil L, Harrison, D Jed, Hochbaum, Daniel R, Kapoor, Vikrant, Klapoetke, Nathan Cao, Kralj, Joel M, Maclaurin, Dougal, Melkonian, Michael, Murthy, Venkatesh N, Sabatini, Bernardo L, Saulnier, Jessica L, Smedemark-Margulies, Niklas, Straub, Christoph, Werley, Christopher A, Wong, Gane Ka-Shu, Zhao, Yongxin, Zou, Peng   +21 more
core   +2 more sources