Results 91 to 100 of about 18,335 (296)

Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems

Advanced Materials, EarlyView.
This article summarizes significant technological advancements in materials, photonic devices, and bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, and on‐skin health monitoring.
Seunghyeb Ban, Hoon Yi, Jaejin Park, Yunuo Huang, Ki Jun Yu, Woon‐Hong Yeo   +5 more
wiley   +1 more source

High fidelity optogenetic control of individual prefrontal cortical pyramidal neurons in vivo [PDF]

, 2012
Precise spatial and temporal manipulation of neural activity in specific genetically defined cell populations is now possible with the advent of optogenetics.
Baratta, Michael V., Cooper, Donald C., Dolzani, Samuel D., Nakamura, Shinya, Pomrenze, Matthew B.   +4 more
core   +3 more sources

Gating mechanisms of a natural anion channelrhodopsin [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance The recently discovered natural anion channelrhodopsins (ACRs) have exceptional properties for use as membrane-hyperpolarizing tools for neural silencing, but our knowledge about them is only rudimentary. We have gained, to our knowledge, first insights into the molecular mechanisms of their unique light-gated anion conductance ...
John L. Spudich, Oleg A. Sineshchekov, Elena G. Govorunova, Hai Li   +3 more
openaire   +3 more sources

A Molecularly Defined Medullary Network for Control of Respiratory Homeostasis

Advanced Science, EarlyView.
The dynamic interplay between central respiratory chemoreceptors and the respiratory central pattern generator is essential for maintaining stable respiratory rhythm and patterns, particularly during sleep. This study offers novel insights into the anatomical, molecular, and functional characteristics of a medullary network involving the nucleus ...
Tianjiao Deng, Xinyi Jing, Liuqi Shao, Yakun Wang, Congrui Fu, Hongxiao Yu, Xiaoyi Wang, Xue Zhao, Fanrao Kong, Yake Ji, Xiaochen Tian, Wei He, Shangyu Bi, Luo Shi, Hanqiao Wang, Fang Yuan, Sheng Wang   +16 more
wiley   +1 more source

Precise multimodal optical control of neural ensemble activity. [PDF]

, 2018
Understanding brain function requires technologies that can control the activity of large populations of neurons with high fidelity in space and time. We developed a multiphoton holographic approach to activate or suppress the activity of ensembles of ...
Adesnik, Hillel, Brohawn, Stephen G, Chesnov, Kirill, Lyall, Evan H, Mardinly, Alan R, Oldenburg, Ian Antón, Pégard, Nicolas C, Sridharan, Savitha, Waller, Laura   +8 more
core   +1 more source

Sodium-Selective Channelrhodopsins

Cells
Channelrhodopsins (ChRs) are light-gated ion channels originally discovered in algae and are commonly used in neuroscience for controlling the electrical activity of neurons with high precision. Initially-discovered ChRs were non-selective cation channels, allowing the flow of multiple ions, such as Na+, K+, H+, and Ca2+, leading to membrane ...
Ariel Coli, Shiqiang Gao, Lars Kaestner
openaire   +2 more sources

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Novel Cerebello-Amygdala Connections Provide Missing Link Between Cerebellum and Limbic System

Frontiers in Systems Neuroscience, 2022
The cerebellum is emerging as a powerful regulator of cognitive and affective processing and memory in both humans and animals and has been implicated in affective disorders. How the cerebellum supports affective function remains poorly understood.
Se Jung Jung, Ksenia Vlasov, Alexa F. D’Ambra, Abhijna Parigi, Mihir Baya, Edbertt Paul Frez, Jacqueline Villalobos, Marina Fernandez-Frentzel, Maribel Anguiano, Yoichiro Ideguchi, Evan G. Antzoulatos, Evan G. Antzoulatos, Diasynou Fioravante, Diasynou Fioravante   +13 more
doaj   +1 more source

Keeping track of worm trackers [PDF]

, 2012
C. elegans is used extensively as a model system in the neurosciences due to its well defined nervous system. However, the seeming simplicity of this nervous system in anatomical structure and neuronal connectivity, at least compared to higher animals ...
Gottschalk, Alexander, Husson, Steven J., Schmitt, Cornelia, Steuer Costa, Wagner   +3 more
core   +1 more source

Genetically‐targeted control of the spinal cord and peripheral nervous system

Journal of Intelligent Medicine, EarlyView.
Application of genetically‐targeted stimulation for treating diseases or injuries outside the brain. Optogenetic and chemogenetic systems have been developed for dysfunction in the cochlea, spinal cord, dorsal root ganglia (DRGs), peripheral nerves, lower urinary tract, and enteric nervous system (ENS). Created with Biorender.com.
Anakaren Romero Lozano, Victoria Koptelova, Zoya Ahmad, Huiliang (Evan) Wang   +3 more
wiley   +1 more source