Results 141 to 150 of about 18,335 (296)
Delivery of time-varying stimuli using ChR2 [PDF]
arXiv, 2013 To understand sensory processing in neuronal populations, it is necessary to deliver stimuli to the sensory organs of animals and record evoked population activity downstream. However, the pathways from sensory input to synaptic currents in cells that are several synapses removed from sensory organs are complex.
arxiv
, 2013 Channelrhodopsins-2 (ChR2) are a class of light sensitive proteins that offer the ability to use light stimulation to regulate neural activity with millisecond precision.
Khargonekar, Pramod P. +3 more
core +1 more source
eLife, 2016 We describe refinements in optogenetic methods for circuit mapping that enable measurements of functional synaptic connectivity with single-neuron resolution.
Christopher A. Baker +3 more
semanticscholar +1 more source
Orexinergic neurons contribute to autonomic cardiovascular regulation for locomotor exercise
The Journal of Physiology, EarlyView.Abstract figure legend This study unveiled the essential role of the orexinergic nervous system in the central circuitry that transmits central command signals for locomotor exercise. We observed the excitation of orexinergic neurons by voluntary locomotor exercise in rats.
Emi Narai +7 more
wiley +1 more source
Optogenetics in primates: monkey see monkey look [PDF]
, 2011 Optogenetics has emerged as a powerful tool for studying the neural basis of simple behaviors in rodents and small animals. In the primate model, however, optogenetics has had limited utility because optical methods have not been able to drive behavior ...
Gregory Horwitz +2 more
core +1 more source
Recent advances in engineering microbial rhodopsins for optogenetics [PDF]
, 2015 Protein engineering of microbial rhodopsins has been successful in generating variants with improved properties for applications in optogenetics.
Arnold, Frances H. +2 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend KV4 channel availability regulates inferior olive action potential duration. The durations of action potentials in inferior olive neurons (blue) depend strongly on preceding membrane potential, with afterdepolarizations varying over the physiological range by almost two orders of magnitude (open circles). Voltage clamp recordings
Ziyad W. Sultan +2 more
wiley +1 more source
Translational Retinal Research and Therapies. [PDF]
, 2018 The following review summarizes the state of the art in representative aspects of gene therapy/translational medicine and evolves from a symposium held at the School of Veterinary Medicine, University of Pennsylvania on November 16, 2017 honoring Dr ...
Aguirre, Gustavo D +7 more
core +1 more source
Resonance Raman and FTIR spectroscopic characterization of the closed and open states of channelrhodopsin-1. [PDF]
, 2014 Channelrhodopsin-1 from Chlamydomonas augustae (CaChR1) is a light-activated cation channel, which is a promising optogenetic tool. We show by resonance Raman spectroscopy and retinal extraction followed by high pressure liquid chromatography (HPLC) that
Bamann, C +5 more
core +1 more source
Activation of Distinct Channelrhodopsin Variants Engages Different Patterns of Network Activity
eNeuro, 2019 Several recently developed Channelrhodopsin (ChR) variants are characterized by rapid kinetics and reduced desensitization in comparison to the widely used ChR2.
Na Young Jun, Jessica A. Cardin
semanticscholar +1 more source