Results 151 to 160 of about 18,335 (296)
Advanced Science, Volume 12, Issue 17, May 8, 2025.This study examines the effects of Shank3 mutation on the mesoaccumbens pathway using a Shank3‐deficient rat model. The findings reveal altered social reward processing in these rats, accompanied by changes in dopaminergic and GABAergic neural activity within the ventral tegmental area (VTA) and dopamine release in the nucleus accumbense (NAc ...
Marie Barbier +4 more
wiley +1 more source
Frontiers in Neural Circuits, 2012 We have mapped intracortical activity in vivo independent of sensory input using arbitrary point channelrhodopsin-2 (ChR2) stimulation and regional voltage sensitive dye imaging in B6.Cg-Tg (Thy1-COP4/EYFP)18Gfng/J transgenic mice.
Diana H Lim +8 more
doaj +1 more source
Brief wide-field photostimuli evoke and modulate oscillatory reverberating activity in cortical networks [PDF]
arXiv, 2016 Cell assemblies manipulation by optogenetics is pivotal to advance neuroscience and neuroengineering. In in vivo applications, photostimulation often broadly addresses a population of cells simultaneously, leading to feed-forward and to reverberating responses in recurrent microcircuits.
arxiv
A history of optogenetics: the development of tools for controlling brain circuits with light [PDF]
, 2011 Understanding how different kinds of neuron in the brain work together to implement sensations, feelings, thoughts, and movements, and how deficits in specific kinds of neuron result in brain diseases, has long been a priority in basic and clinical ...
Boyden, Edward Stuart
core +2 more sources
Crystal structure of a natural light-gated anion channelrhodopsin
bioRxiv, 2018 The anion channelrhodopsin GtACR1 from the alga Guillardia theta is a potent neuron-inhibiting optogenetics tool. Presented here, its X-ray structure at 2.9 Å reveals a tunnel traversing the protein from its extracellular surface to a large cytoplasmic ...
Hai Li +7 more
semanticscholar +1 more source
Astrocytes Mediate Psychostimulant‐Induced Alterations of Spike‐Timing Dependent Synaptic Plasticity
Glia, Volume 73, Issue 5, Page 1051-1067, May 2025.Main Points Cocaine and amphetamine stimulates astrocytes and downregulates the GLT‐1. The dysfunction in GLT‐1 modify EPSP kinetics and modulate STDP, switching LTP to LTD in psychostimulant‐treated mice. These effects were restored by upregulation of GLT‐1.
Samuel Alberquilla +7 more
wiley +1 more source
MedComm, Volume 6, Issue 5, May 2025.Reactive astrocytes release various molecules, which play a role in maintaining central nervous system (CNS) homeostasis. (1) Gliotransmitters, such as glutamate, γ‐aminobutyric acid (GABA), ATP, and D‐serine, are secreted by vesicular exocytosis. In addition, astrocytes can also release ATP and glutamate through (2) P2X7Rs, (3) connexin‐43 (Cx43 ...
Peter Illes +4 more
wiley +1 more source
Design and Implementation of a Simulation Framework for a Bio–Neural Dust System
ModellingThis paper presents the development of a computer simulation framework, designed as a cost–effective and technically efficient alternative to experimental studies.
Oussama Abderrahmane Dambri +5 more
doaj +1 more source
Time-resolved infrared spectroscopic techniques as applied to Channelrhodopsin
Frontiers in Molecular Biosciences, 2015 Among optogenetic tools, channelrhodopsins, the light gated ion channels of the plasma membrane from green algae, play the most important role. Properties like channel selectivity, timing parameters or color can be influenced by the exchange of selected ...
Eglof eRitter +6 more
doaj +1 more source
Protein Science, Volume 34, Issue 5, May 2025.Abstract Near‐infrared (NIR) fluorescent proteins and optogenetic tools derived from bacterial phytochromes' photosensory core modules (PCMs) operate within the first (NIR‐I) tissue transparency window under single‐photon activation. Leveraging two‐photon (2P) light in the second transparency window (NIR‐II) for photoswitching bacterial phytochromes ...
Diana Galiakhmetova +11 more
wiley +1 more source