Results 281 to 290 of about 18,335 (296)

Conformational Changes of Channelrhodopsin-2

Journal of the American Chemical Society, 2009
Channelrhodopsin-2 (ChR2) is a member of the new class of light-gated ion channels which serve as phototaxis receptors in the green alga Chlamydomonas reinhardtii. The protein is employed in optogenetics where neural circuits are optically stimulated under high spatiotemporal control.
Radu, Ionela, Bamann, Christian, Nack, Melanie, Nagel, Georg, Bamberg, Ernst, Heberle, Joachim   +5 more
openaire   +3 more sources

Structural insights into ion conduction by channelrhodopsin 2 [PDF]

Science, 2017
The inner workings of an optogenetic tool Channelrhodopsins are membrane channel proteins whose gating is controlled by light. In their native setting, they allow green algae to move in response to light. Their expression in neurons allows precise control of neural activity, an approach known as optogenetics.
O. Volkov, K. Kovalev, V. Polovinkin, V. Borshchevskiy, C. Bamann, R. Astashkin, E. Marin, A. Popov, T. Balandin, D. Willbold, G. Büldt, E. Bamberg, V. Gordeliy   +12 more
semanticscholar   +6 more sources

Green-Sensitive, Long-Lived, Step-Functional Anion Channelrhodopsin-2 Variant as a High-Potential Neural Silencing Tool.

Journal of Physical Chemistry Letters, 2020
Anion channelrhodopsin-2 (GtACR2) was identified from the alga Guillardia theta as a light-gated anion channel, providing a powerful neural silencing tool for optogenetics. To expand its molecular properties, we produced here GtACR2 variants by strategic
Keiichi Kojima, N. Miyoshi, Atsushi Shibukawa, Srikanta Chowdhury, Masaki Tsujimura, Tomoyasu Noji, Hiroshi Ishikita, A. Yamanaka, Y. Sudo   +8 more
semanticscholar   +1 more source

Exciton Circular Dichroism in Channelrhodopsin

The Journal of Physical Chemistry B, 2014
Channelrhodopsins (ChRs) are of great interest currently because of their important applications in optogenetics, the photostimulation of neurons. The absorption and circular dichroism (CD) spectra of C1C2, a chimera of ChR1 and ChR2 of Chlamydomonas reinhardtii, have been studied experimentally and theoretically.
PESCITELLI, GENNARO, Hideaki E. Kato, Satomi Oishi, Jumpei Ito, Andrés Daniel Maturana, Osamu Nureki, Robert W. Woody   +6 more
openaire   +3 more sources

Enhancing Channelrhodopsins: An Overview

2016
After the discovery of Channelrhodopsin, a light-gated ion channel, only a few people saw the diverse range of applications for such a protein. Now, more than 10 years later Channelrhodopsins have become widely accepted as the ultimate tool to control the membrane potential of excitable cells via illumination.
Matthias Prigge, Jonas Wietek
openaire   +2 more sources

Structure–Function Relationship of Channelrhodopsins

2021
Ion-translocating rhodopsins, especially channelrhodopsins (ChRs), have attracted broad attention as a powerful tool to modulate the membrane potential of cells with light (optogenetics). Because of recent biophysical, spectroscopic, and computational studies, including the structural determination of cation and anion ChRs, our understanding of the ...
openaire   +3 more sources

Evolution of the Channelrhodopsin Photocycle Model

ChemPhysChem, 2010
AbstractMany processes in green algae are under control of rhodopsin‐type photoreceptors, but only a few have been studied at least in some detail in the past. Up to now, functionally and biochemically only the channelrhodpsins ChR1 and ChR2 are characterized.
Katja Stehfest, Peter Hegemann
openaire   +2 more sources

Characterization of metagenomically identified channelrhodopsins

2021
Kanalrhodopsine (ChRs), lichtgesteuerte Ionenkanäle, vermitteln phototaktische Reaktionen in beweglichen Algen und sind als optogenetische Werkzeuge zur Manipulation der Zellaktivität mittels Lichts weit verbreitet. Viele Kationen- und Anionen-leitende ChRs (CCRs und ACRs) wurden aus kultivierbaren Chlorophyten- und Cryptophytenarten identifiziert. Die
openaire   +3 more sources

Channelrhodopsin reveals its dark secrets

Science, 2017
A high-resolution structure of channelrhodopsin 2 provides key insights for ...
openaire   +2 more sources

Structure-Functional Analysis of Channelrhodopsins [PDF]

, 2015
Channelrhodopsin (ChR) was the first light-gated cation channel to be discovered from green algae. Since the inward flow of cations triggers neuron firing, neurons expressing ChRs can be optically controlled, even within freely moving mammals. Although ChR has been broadly applied to neuroscience research, little is known about its molecular mechanisms.
Ryuichiro Ishitani, Osamu Nureki, Hideaki E. Kato   +2 more
openaire   +1 more source