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Optogenetics and deep brain stimulation neurotechnologies [PDF]
, 2015 Brain neural network is composed of densely packed, intricately wired neurons whose activity patterns ultimately give rise to every behavior, thought, or emotion that we experience. Over the past decade, a novel neurotechnique, optogenetics that combines
A Berndt +58 more
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Channelrhodopsins: A bioinformatics perspective
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2014 Channelrhodopsins are microbial-type rhodopsins that function as light-gated cation channels. Understanding how the detailed architecture of the protein governs its dynamics and specificity for ions is important, because it has the potential to assist in designing site-directed channelrhodopsin mutants for specific neurobiology applications.
Coral del Val +3 more
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A wirelessly controlled implantable LED system for deep brain optogenetic stimulation
Frontiers in Integrative Neuroscience, 2015 In recent years optogenetics has rapidly become an essential technique in neuroscience. Its temporal and spatial specificity, combined with efficacy in manipulating neuronal activity, are especially useful in studying the behavior of awake behaving ...
Mark A. Rossi +7 more
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Photonics, 2019 Dissecting the functional roles of neuronal circuits and their interaction is a crucial step in basic neuroscience and in all the biomedical field. Optogenetics is well-suited to this purpose since it allows us to study the functionality of neuronal ...
Elena Montagni +3 more
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Timing Control of Single Neuron Spikes with Optogenetic Stimulation [PDF]
, 2018 This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a cortical neuron'
Eckford, Andrew W. +3 more
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Diversity of Chlamydomonas Channelrhodopsins [PDF]
Photochemistry and Photobiology, 2011 AbstractChannelrhodopsins act as photoreceptors for control of motility behavior in flagellates and are widely used as genetically targeted tools to optically manipulate the membrane potential of specific cell populations (“optogenetics”). The first two channelrhodopsins were obtained from the model organism Chlamydomonas reinhardtii (CrChR1 and CrChR2)
Sing-Yi, Hou +6 more
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Frontiers in Cellular Neuroscience, 2019 Neuronal activity is thought to drive the remodeling of circuits in the mammalian cerebral cortex. However, its precise function in the underlying formation and elimination of glutamatergic synapses has remained controversial.
Dylan P. Quinn +6 more
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Practical considerations in an era of multicolor optogenetics
Frontiers in Cellular Neuroscience, 2023 The ability to control synaptic communication is indispensable to modern neuroscience. Until recently, only single-pathway manipulations were possible due to limited availability of opsins activated by distinct wavelengths.
Daniel J. Rindner, Gyorgy Lur
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From channelrhodopsins to optogenetics
EMBO Molecular Medicine, 2013 We did not expect that research on the molecular mechanism of algal phototaxis or archaeal light‐driven ion transport might interest readers of a medical journal when we conceived and performed our experiments a decade ago. On the other hand, it did not escape our attention that channelrhodopsin is helping an ever‐increasing number of researchers to ...
Hegemann, Peter, Nagel, Georg
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Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance
eLife, 2020 The prefrontal cortex (PFC) integrates incoming information to guide our actions. When motivation for food-seeking competes with avoidance of danger, the PFC likely plays a role in selecting the optimal choice. In platform-mediated active avoidance, rats
Maria M Diehl +6 more
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