Results 31 to 40 of about 18,484 (195)
Utility of red‐light ultrafast optogenetic stimulation of the auditory pathway
EMBO Molecular Medicine, 2021 Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future alternative to electrical stimulation used in current cochlear implants. Here, we employed fast and very fast variants of the red‐light‐activated channelrhodopsin (ChR)
Burak Bali +6 more
doaj +1 more source
Dampening Spontaneous Activity Improves the Light Sensitivity and Spatial Acuity of Optogenetic Retinal Prosthetic Responses [PDF]
, 2016 Retinitis pigmentosa is a progressive retinal dystrophy that causes irreversible visual impairment and blindness. Retinal prostheses currently represent the only clinically available vision-restoring treatment, but the quality of vision returned remains ...
Barrett, John Martin +2 more
core +1 more source
The Desensitized Channelrhodopsin‐2 Photointermediate Contains 13 ‐cis, 15 ‐syn Retinal Schiff Base
Angewandte Chemie, 2021 Channelrhodopsin‐2 (ChR2) is a light‐gated cation channel and was used to lay the foundations of optogenetics. Its dark state X‐ray structure has been determined in 2017 for the wild‐type, which is the prototype for all other ChR variants.
Johanna Becker‐Baldus +5 more
semanticscholar +1 more source
Frontiers in Systems Neuroscience, 2018 Quantitative analysis of corticocortical signaling is needed to understand and model information processing in cerebral networks. However, higher-order pathways, hodologically remote from sensory input, are not amenable to spatiotemporally precise ...
Xiaojian Li +6 more
doaj +1 more source
Optogenetics and deep brain stimulation neurotechnologies [PDF]
, 2015 Brain neural network is composed of densely packed, intricately wired neurons whose activity patterns ultimately give rise to every behavior, thought, or emotion that we experience. Over the past decade, a novel neurotechnique, optogenetics that combines
A Berndt +58 more
core +2 more sources
Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex
eLife, 2018 Much is known about the neural circuits of conditioned fear and its relevance to understanding anxiety disorders, but less is known about other anxiety-related behaviors such as active avoidance.
Maria M Diehl +6 more
doaj +1 more source
Extending the Anion Channelrhodopsin-Based Toolbox for Plant Optogenetics
Membranes, 2021 Optogenetics was developed in the field of neuroscience and is most commonly using light-sensitive rhodopsins to control the neural activities. Lately, we have expanded this technique into plant science by co-expression of a chloroplast-targeted β ...
Yang Zhou +5 more
semanticscholar +1 more source
A wirelessly controlled implantable LED system for deep brain optogenetic stimulation
Frontiers in Integrative Neuroscience, 2015 In recent years optogenetics has rapidly become an essential technique in neuroscience. Its temporal and spatial specificity, combined with efficacy in manipulating neuronal activity, are especially useful in studying the behavior of awake behaving ...
Mark A. Rossi +7 more
doaj +1 more source
In Utero Electroporation for Manipulation of Specific Neuronal Populations
Membranes, 2022 The complexity of brain functions is supported by the heterogeneity of brain tissue and millisecond-scale information processing. Understanding how complex neural circuits control animal behavior requires the precise manipulation of specific neuronal ...
Kotaro Yamashiro +2 more
doaj +1 more source
Timing Control of Single Neuron Spikes with Optogenetic Stimulation [PDF]
, 2018 This paper predicts the ability to externally control the firing times of a cortical neuron whose behavior follows the Izhikevich neuron model. The Izhikevich neuron model provides an efficient and biologically plausible method to track a cortical neuron'
Eckford, Andrew W. +3 more
core +2 more sources