Results 41 to 50 of about 18,335 (296)
Ion Selectivity and Competition in Channelrhodopsins [PDF]
Biophysical Journal, 2013 Channelrhodopsins are light-gated ion channels of green algae. They are widely used for the analysis of neuronal networks using light in the emerging field of optogenetics. Under steady-state light conditions, the two open states, O1 and O2, mediate the photocurrents with different ion conductance and selectivity.
Schneider, Franziska +2 more
openaire +4 more sources
Optogenetics in Alzheimer’s Disease: Focus on Astrocytes
Antioxidants, 2023 Alzheimer’s disease (AD) is the most common form of dementia, resulting in disability and mortality. The global incidence of AD is consistently surging.
Elena Mitroshina +2 more
doaj +1 more source
Non-viral delivery and optimized optogenetic stimulation of retinal ganglion cells led to behavioral restoration of vision [PDF]
, 2012 Stimulation of retinal neurons using optogenetics via use of chanelrhodopsin-2 (ChR2) has opened up a new direction for restoration of vision for treatment of retinitis pigmentosa (RP).
Edward Wong +5 more
core +2 more sources
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2014 A two-domain elevator mechanism for sodium/proton antiport Chiara Lee, Hae Joo Kang, Christoph von Ballmoos, Simon Newstead, Povilas Uzdavinys, David L. Dotson, So Iwata, Oliver Beckstein, Alexander D. Cameron, David Drew Division of Molecular Biosciences, Imperial College London, London SW7 2AZ, UK Centre for Biomembrane Research, Department of ...
Robert Bittl +10 more
openaire +2 more sources
Photonics, 2019 Dissecting the functional roles of neuronal circuits and their interaction is a crucial step in basic neuroscience and in all the biomedical field. Optogenetics is well-suited to this purpose since it allows us to study the functionality of neuronal ...
Elena Montagni +3 more
doaj +1 more source
Fast targeted gene transfection and optogenetic modification of single neurons using femtosecond laser irradiation [PDF]
, 2013 This work is supported by the UK Engineering Physical Sciences Research Council (EPSRC).A prevailing problem in neuroscience is the fast and targeted delivery of DNA into selected neurons.
Antkowiak, Maciej +5 more
core +1 more source
Proton transfer pathway in anion channelrhodopsin-1
eLife, 2021 Anion channelrhodopsin from Guillardia theta (GtACR1) has Asp234 (3.2 Å) and Glu68 (5.3 Å) near the protonated Schiff base. Here, we investigate mutant GtACR1s (e.g., E68Q/D234N) expressed in HEK293 cells.
Masaki Tsujimura +4 more
semanticscholar +1 more source
Channelrhodopsins: A bioinformatics perspective
Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2014 Channelrhodopsins are microbial-type rhodopsins that function as light-gated cation channels. Understanding how the detailed architecture of the protein governs its dynamics and specificity for ions is important, because it has the potential to assist in designing site-directed channelrhodopsin mutants for specific neurobiology applications.
Coral del Val +3 more
openaire +3 more sources
Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex
eLife, 2018 Much is known about the neural circuits of conditioned fear and its relevance to understanding anxiety disorders, but less is known about other anxiety-related behaviors such as active avoidance.
Maria M Diehl +6 more
doaj +1 more source
Functional cardiac imaging by random access microscopy
Frontiers in Physiology, 2014 Advances in the development of voltage sensitive dyes and Ca2+ sensors in combination with innovative microscopy techniques allowed researchers to perform functional measurements with an unprecedented spatial and temporal resolution.
Claudia eCrocini +7 more
doaj +1 more source