Results 41 to 50 of about 17,118 (247)

Light-Induced Helix Movements in Channelrhodopsin-2

Journal of Molecular Biology, 2014
Channelrhodopsin-2 (ChR2) is a cation-selective light-gated channel from Chlamydomonas reinhardtii (Nagel G, Szellas T, Huhn W, Kateriya S, Adeishvili N, Berthold P, et al. Channelrhodopsin-2, a directly light-gated cation-selective membrane channel. Proc Natl Acad Sci USA 2003;100:13940-5), which has become a powerful tool in optogenetics.
Maria Müller, Christian Bamann, Ernst Bamberg, Werner Kühlbrandt   +3 more
openalex   +6 more sources

Rectification of the Channelrhodopsin Early Conductance [PDF]

Biophysical Journal, 2011
We analyzed the nonlinear current-voltage relationships of the early conducting state of channelrhodopsin-2 expressed in Xenopus oocytes and human embryonic kidney cells with respect to changes of the electrochemical gradients of H(+), Na(+)/K(+), and Ca(2+)/Mg(2+).
Gradmann, Dietrich, Berndt, Andre, Schneider, Franziska, Hegemann, Peter   +3 more
openaire   +3 more sources

Optogenetic perturbations reveal the dynamics of an oculomotor integrator [PDF]

, 2014
Many neural systems can store short-term information in persistently firing neurons. Such persistent activity is believed to be maintained by recurrent feedback among neurons.
Arrenberg, AB, Baier, H, Gonçalves, PJ, Hablitzel, B, Machens, CK   +4 more
core   +2 more sources

Structural Foundations of Potassium Selectivity in Channelrhodopsins

mBio, 2022
Recently discovered microbial light-gated ion channels (channelrhodopsins) with a higher permeability for K + than for Na + (potassium-selective channelrhodopsins [kalium channelrhodopsins, or KCRs]) demonstrate an alternative K +
Elena G. Govorunova, Oleg A. Sineshchekov, Leonid S. Brown, Ana-Nicoleta Bondar, John L. Spudich   +4 more
openaire   +4 more sources

Specificity, Versatility, and Continual Development: The Power of Optogenetics for Epilepsy Research

Frontiers in Cellular Neuroscience, 2018
Optogenetics is a powerful and rapidly expanding set of techniques that use genetically encoded light sensitive proteins such as opsins. Through the selective expression of these exogenous light-sensitive proteins, researchers gain the ability to ...
Zoé Christenson Wick, Esther Krook-Magnuson   +1 more
doaj   +1 more source

Anion channelrhodopsins for inhibitory cardiac optogenetics [PDF]

Scientific Reports, 2016
AbstractOptical control of the heart muscle is a promising strategy for cardiology because it is more specific than traditional electrical stimulation, and allows a higher temporal resolution than pharmacological interventions. Anion channelrhodopsins (ACRs) from cryptophyte algae expressed in cultured neonatal rat ventricular cardiomyocytes produced ...
Elena G. Govorunova, Shane R. Cunha, Oleg A. Sineshchekov, John L. Spudich   +3 more
openaire   +2 more sources

Precise excitation-inhibition balance controls gain and timing in the hippocampus

eLife, 2019
Excitation-inhibition (EI) balance controls excitability, dynamic range, and input gating in many brain circuits. Subsets of synaptic input can be selected or 'gated' by precise modulation of finely tuned EI balance, but assessing the granularity of EI ...
Aanchal Bhatia, Sahil Moza, Upinder Singh Bhalla   +2 more
doaj   +1 more source

Sodium-Selective Channelrhodopsins

Cells
Channelrhodopsins (ChRs) are light-gated ion channels originally discovered in algae and are commonly used in neuroscience for controlling the electrical activity of neurons with high precision. Initially-discovered ChRs were non-selective cation channels, allowing the flow of multiple ions, such as Na+, K+, H+, and Ca2+, leading to membrane ...
Ariel Coli, Shiqiang Gao, Lars Kaestner
openaire   +3 more sources

Gating in channelrhodopsin

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2014
A two-domain elevator mechanism for sodium/proton antiport Chiara Lee, Hae Joo Kang, Christoph von Ballmoos, Simon Newstead, Povilas Uzdavinys, David L. Dotson, So Iwata, Oliver Beckstein, Alexander D. Cameron, David Drew Division of Molecular Biosciences, Imperial College London, London SW7 2AZ, UK Centre for Biomembrane Research, Department of ...
Lórenz-Fonfría, Víctor A., Resler, Tom, Krause, Nils, Engelhard, Christopher, Bittl, Robert, Neumann-Verhoefen, Mirka, Wachtveitl, Josef, Bamann, Christian, Bamberg, Ernst, Schlesinger, Ramona, Heberle, Joachim   +10 more
openaire   +1 more source

High fidelity optogenetic control of individual prefrontal cortical pyramidal neurons in vivo [PDF]

, 2012
Precise spatial and temporal manipulation of neural activity in specific genetically defined cell populations is now possible with the advent of optogenetics.
Baratta, Michael V., Cooper, Donald C., Dolzani, Samuel D., Nakamura, Shinya, Pomrenze, Matthew B.   +4 more
core   +3 more sources