Results 41 to 50 of about 18,484 (195)
Photonics, 2019 Dissecting the functional roles of neuronal circuits and their interaction is a crucial step in basic neuroscience and in all the biomedical field. Optogenetics is well-suited to this purpose since it allows us to study the functionality of neuronal ...
Elena Montagni +3 more
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Scientific Reports, 2021 Ion channel proteins are physiologically important molecules in living organisms. Their molecular functions have been investigated using electrophysiological methods, which enable quantitative, precise and advanced measurements and thus require complex ...
C. Kikuchi +5 more
semanticscholar +1 more source
Proton transfer pathway in anion channelrhodopsin-1
eLife, 2021 Anion channelrhodopsin from Guillardia theta (GtACR1) has Asp234 (3.2 Å) and Glu68 (5.3 Å) near the protonated Schiff base. Here, we investigate mutant GtACR1s (e.g., E68Q/D234N) expressed in HEK293 cells.
Masaki Tsujimura +4 more
semanticscholar +1 more source
Frontiers in Cellular Neuroscience, 2019 Neuronal activity is thought to drive the remodeling of circuits in the mammalian cerebral cortex. However, its precise function in the underlying formation and elimination of glutamatergic synapses has remained controversial.
Dylan P. Quinn +6 more
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Practical considerations in an era of multicolor optogenetics
Frontiers in Cellular Neuroscience, 2023 The ability to control synaptic communication is indispensable to modern neuroscience. Until recently, only single-pathway manipulations were possible due to limited availability of opsins activated by distinct wavelengths.
Daniel J. Rindner, Gyorgy Lur
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Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance
eLife, 2020 The prefrontal cortex (PFC) integrates incoming information to guide our actions. When motivation for food-seeking competes with avoidance of danger, the PFC likely plays a role in selecting the optimal choice. In platform-mediated active avoidance, rats
Maria M Diehl +6 more
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Optogenetic perturbations reveal the dynamics of an oculomotor integrator [PDF]
, 2014 Many neural systems can store short-term information in persistently firing neurons. Such persistent activity is believed to be maintained by recurrent feedback among neurons.
Arrenberg, AB +4 more
core +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance People for centuries are puzzled how living creatures like plants sense their environment. Plants employ electrical signals to communicate a cue-dependent local status between plants cells and organs.
Antonella Reyer +11 more
semanticscholar +1 more source
bioRxiv, 2021 Optogenetic manipulation of genetically-specified neuron populations has become a key tool in circuit neuroscience. The medial amygdala (MeA) receives pheromone information about conspecifics and has crucial functions in social behaviors; interestingly ...
Aiste Baleisyte +2 more
semanticscholar +1 more source
Specificity, Versatility, and Continual Development: The Power of Optogenetics for Epilepsy Research
Frontiers in Cellular Neuroscience, 2018 Optogenetics is a powerful and rapidly expanding set of techniques that use genetically encoded light sensitive proteins such as opsins. Through the selective expression of these exogenous light-sensitive proteins, researchers gain the ability to ...
Zoé Christenson Wick +1 more
doaj +1 more source