Results 51 to 60 of about 18,335 (296)

Dampening Spontaneous Activity Improves the Light Sensitivity and Spatial Acuity of Optogenetic Retinal Prosthetic Responses [PDF]

, 2016
Retinitis pigmentosa is a progressive retinal dystrophy that causes irreversible visual impairment and blindness. Retinal prostheses currently represent the only clinically available vision-restoring treatment, but the quality of vision returned remains ...
Barrett, John Martin, Hilgen, Gerrit, Sernagor, Evelyne   +2 more
core   +1 more source

Structural Foundations of Potassium Selectivity in Channelrhodopsins

mBio, 2022
Recently discovered microbial light-gated ion channels (channelrhodopsins) with a higher permeability for K + than for Na + (potassium-selective channelrhodopsins [kalium channelrhodopsins, or KCRs]) demonstrate an alternative K + selectivity mechanism, unrelated to ...
Elena G. Govorunova, Oleg A. Sineshchekov, Leonid S. Brown, Ana-Nicoleta Bondar, John L. Spudich   +4 more
openaire   +4 more sources

A wirelessly controlled implantable LED system for deep brain optogenetic stimulation

Frontiers in Integrative Neuroscience, 2015
In recent years optogenetics has rapidly become an essential technique in neuroscience. Its temporal and spatial specificity, combined with efficacy in manipulating neuronal activity, are especially useful in studying the behavior of awake behaving ...
Mark A. Rossi, Vinson eGo, Tracy eMurphy, Quanhai eFu, James eMorizio, Henry H Yin, Henry H Yin, Henry H Yin   +7 more
doaj   +1 more source

Optogenetic control of genetically-targeted pyramidal neuron activity in prefrontal cortex [PDF]

, 2012
A salient feature of prefrontal cortex organization is the vast diversity of cell types that support the temporal integration of events required for sculpting future responses. A major obstacle in understanding the
Donald Cooper, Donald Cooper, Matthew Pomrenze, Michael Baratta, Peter Dobelis, Samuel Dolzani, Shinya Nakamura   +6 more
core   +4 more sources

Optogenetic stimulation of medial amygdala GABA neurons with kinetically different channelrhodopsin variants yield opposite behavioral outcomes

bioRxiv, 2021
Optogenetic manipulation of genetically-specified neuron populations has become a key tool in circuit neuroscience. The medial amygdala (MeA) receives pheromone information about conspecifics and has crucial functions in social behaviors; interestingly ...
Aiste Baleisyte, R. Schneggenburger, O. Kochubey   +2 more
semanticscholar   +1 more source

Channelrhodopsin-2 is a leaky proton pump [PDF]

Proceedings of the National Academy of Sciences, 2009
Since its discovery, the light-gated cation channel Channelrhodopsin-2 (ChR2) has proven to be a long-sought tool for the noninvasive, light-activated control of neural cells in culture and in living animals. Although ChR2 is widely used in neurobiological applications, little is known about its molecular mechanism.
Christian Bamann, Verena Pintschovius, Ernst Bamberg, Dirk Zimmermann, Katrin Feldbauer, Julia Spitz   +5 more
openaire   +3 more sources

Biophysical properties of optogenetic tools and their application for vision restoration approaches.

Frontiers in Systems Neuroscience, 2016
Optogenetics is the use of genetically encoded light-activated proteins to manipulate cells in a minimally invasive way using light. The most prominent example is channelrhodopsin2 (ChR2), which allows the activation of electrically excitable cells via ...
Simon Darius Klapper, Anka Swiersy, Ernst Bamberg, Volker Busskamp   +3 more
doaj   +1 more source

Signal generation and storage in FRET-based nanocommunications [PDF]

Nano Communication Networks, Volume 21, September 2019, 100254, 2018
The paper is concerned with Forster Resonance Energy Transfer (FRET) considered as a mechanism for communication between nanodevices. Two solved issues are reported in the paper, namely: signal generation and signal storage in FRET-based nanonetworks.
arxiv   +1 more source

Optogenetics and deep brain stimulation neurotechnologies [PDF]

, 2015
Brain neural network is composed of densely packed, intricately wired neurons whose activity patterns ultimately give rise to every behavior, thought, or emotion that we experience. Over the past decade, a novel neurotechnique, optogenetics that combines
A Berndt, A Berndt, A Priori, AA Kuhn, AA Kuhn, AS Chuong, B Sauer, B Wingeier, BY Chow, BY Chow, C Bamann, D Luo, D Oesterhelt, D Oesterhelt, D Williams, ES Boyden, EY Uc, F Zhang, F Zhang, G Foffani, G Miesenbock, G Nagel, J Cavanaugh, J Mobley, J Volkmann, J Wells, J Wietek, JG Bernstein, JG Bernstein, JG Bernstein, JL Spudich, JL Spudich, JO Dostrovsky, JZ Tsien, L Bekar, L Madisen, LA Gunaydin, M Weinberger, M Weinberger, MC Rodriguez-Oroz, MJ Lehmkuhle, ML Welter, MM Doroudchi, O Yizhar, P Brown, P Silberstein, R Levy, R Levy, R Levy, R Waehler, S Zhao, TW Chen, VC Anderson, X Han, X Han, X Han, X Han, X Han, X Liu   +58 more
core   +2 more sources

Channelrhodopsin-mediated optogenetics highlights a central role of depolarization-dependent plant proton pumps

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance People for centuries are puzzled how living creatures like plants sense their environment. Plants employ electrical signals to communicate a cue-dependent local status between plants cells and organs.
Antonella Reyer, Melanie Häßler, S. Scherzer, Shouguang Huang, J. T. Pedersen, Khaled A S Al-Rascheid, E. Bamberg, M. Palmgren, I. Dreyer, G. Nagel, R. Hedrich, D. Becker   +11 more
semanticscholar   +1 more source