Results 51 to 60 of about 17,118 (247)
The form and function of channelrhodopsin [PDF]
Science, 2017 From biophysics to neuroscience tools The channelrhodopsins and their distinctive light-activated ion channels have emerged as major tools in modern biological research. Deisseroth and Hegemann review the structural and functional properties of these protein photoreceptors.
Karl Deisseroth, Peter Hegemann
openaire +2 more sources
Longitudinal Optogenetic Motor Mapping Revealed Structural and Functional Impairments and Enhanced Corticorubral Projection after Contusive Spinal Cord Injury in Mice [PDF]
, 2019 Current evaluation of impairment and repair after spinal cord injury (SCI) is largely dependent on behavioral assessment and histological analysis of injured tissue and pathways. Here, we evaluated whether transcranial optogenetic mapping of motor cortex
Chai, Zhi +5 more
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The clinical potential of optogenetic interrogation of pathogenesis
Clinical and Translational Medicine, 2023 Background Opsin‐based optogenetics has emerged as a powerful biomedical tool using light to control protein conformation. Such capacity has been initially demonstrated to control ion flow across the cell membrane, enabling precise control of action ...
Tianyu Terry Gao +8 more
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Finite-State Channel Models for Signal Transduction in Neural Systems
, 2016 Information theory provides powerful tools for understanding communication systems. This analysis can be applied to intercellular signal transduction, which is a means of chemical communication among cells and microbes.
Eckford, Andrew W. +2 more
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Keeping track of worm trackers [PDF]
, 2012 C. elegans is used extensively as a model system in the neurosciences due to its well defined nervous system. However, the seeming simplicity of this nervous system in anatomical structure and neuronal connectivity, at least compared to higher animals ...
Gottschalk, Alexander +3 more
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Spatiotemporal Control of GPR37 Signaling and Its Behavioral Effects by Optogenetics
Frontiers in Molecular Neuroscience, 2018 Despite the progress in deorphanization of G Protein-Coupled Receptors (GPCRs), ≈100 GPCRs are still classified as orphan receptors without identified endogenous ligands and with unknown physiological functions.
Wu Zheng +20 more
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In Utero Electroporation for Manipulation of Specific Neuronal Populations
Membranes, 2022 The complexity of brain functions is supported by the heterogeneity of brain tissue and millisecond-scale information processing. Understanding how complex neural circuits control animal behavior requires the precise manipulation of specific neuronal ...
Kotaro Yamashiro +2 more
doaj +1 more source
Optical excitation and detection of neuronal activity [PDF]
, 2017 Optogenetics has emerged as an exciting tool for manipulating neural activity, which in turn, can modulate behavior in live organisms. However, detecting the response to the optical stimulation requires electrophysiology with physical contact or ...
Gillette, Martha +8 more
core +2 more sources
Frontiers in Human Neuroscience, 2010 Selective optogenetic drive of fast spiking interneurons (FS) leads to enhanced local field potential (LFP) power across the traditional gamma frequency band (20-80Hz; Cardin et al., 2009).
Dorea Vierling-Claassen +4 more
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Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording
Micromachines, 2021 During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several technological advances in light delivery devices.
Saeyeong Jeon +6 more
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