Optogenetics: Background, Methodological Advances and Potential Applications for Cardiovascular Research and Medicine [PDF]
, 2020 Optogenetics is an elegant approach of precisely controlling and monitoring the biological functions of a cell, group of cells, tissues, or organs with high temporal and spatial resolution by using optical system and genetic engineering technologies. The
Joshi, Jyotsna +2 more
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Machine learning-guided channelrhodopsin engineering enables minimally-invasive optogenetics
Nature Methods, 2019 We engineered light-gated channelrhodopsins (ChRs) whose current strength and light sensitivity enable minimally invasive neuronal circuit interrogation. Current ChR tools applied to the mammalian brain require intracranial surgery for transgene delivery
C. N. Bedbrook +5 more
semanticscholar +1 more source
Precise excitation-inhibition balance controls gain and timing in the hippocampus
eLife, 2019 Excitation-inhibition (EI) balance controls excitability, dynamic range, and input gating in many brain circuits. Subsets of synaptic input can be selected or 'gated' by precise modulation of finely tuned EI balance, but assessing the granularity of EI ...
Aanchal Bhatia +2 more
doaj +1 more source
High fidelity optogenetic control of individual prefrontal cortical pyramidal neurons in vivo [PDF]
, 2012 Precise spatial and temporal manipulation of neural activity in specific genetically defined cell populations is now possible with the advent of optogenetics.
Baratta, Michael V. +4 more
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Optical excitation and detection of neuronal activity [PDF]
, 2017 Optogenetics has emerged as an exciting tool for manipulating neural activity, which in turn, can modulate behavior in live organisms. However, detecting the response to the optical stimulation requires electrophysiology with physical contact or ...
Gillette, Martha +8 more
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Suppression of epileptic seizures by transcranial activation of K+-selective channelrhodopsin
bioRxivOptogenetics is a valuable tool for studying the mechanisms of neurological diseases and is now being developed for therapeutic applications. In rodents and macaques, improved channelrhodopsins have been applied to achieve transcranial optogenetic ...
Xiaodong Duan +16 more
semanticscholar +1 more source
Finite-State Channel Models for Signal Transduction in Neural Systems
, 2016 Information theory provides powerful tools for understanding communication systems. This analysis can be applied to intercellular signal transduction, which is a means of chemical communication among cells and microbes.
Eckford, Andrew W. +2 more
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Keeping track of worm trackers [PDF]
, 2012 C. elegans is used extensively as a model system in the neurosciences due to its well defined nervous system. However, the seeming simplicity of this nervous system in anatomical structure and neuronal connectivity, at least compared to higher animals ...
Gottschalk, Alexander +3 more
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Implantable Optrode Array for Optogenetic Modulation and Electrical Neural Recording
Micromachines, 2021 During the last decade, optogenetics has become an essential tool for neuroscience research due to its unrivaled feature of cell-type-specific neuromodulation. There have been several technological advances in light delivery devices.
Saeyeong Jeon +6 more
doaj +1 more source
Longitudinal Optogenetic Motor Mapping Revealed Structural and Functional Impairments and Enhanced Corticorubral Projection after Contusive Spinal Cord Injury in Mice [PDF]
, 2019 Current evaluation of impairment and repair after spinal cord injury (SCI) is largely dependent on behavioral assessment and histological analysis of injured tissue and pathways. Here, we evaluated whether transcranial optogenetic mapping of motor cortex
Chai, Zhi +5 more
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