Results 61 to 70 of about 18,335 (296)
From channelrhodopsins to optogenetics
EMBO Molecular Medicine, 2013 We did not expect that research on the molecular mechanism of algal phototaxis or archaeal light‐driven ion transport might interest readers of a medical journal when we conceived and performed our experiments a decade ago. On the other hand, it did not escape our attention that channelrhodopsin is helping an ever‐increasing number of researchers to ...
Hegemann, Peter, Nagel, Georg
openaire +4 more sources
Frontiers in Systems Neuroscience, 2018 Quantitative analysis of corticocortical signaling is needed to understand and model information processing in cerebral networks. However, higher-order pathways, hodologically remote from sensory input, are not amenable to spatiotemporally precise ...
Xiaojian Li +6 more
doaj +1 more source
Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance
eLife, 2020 The prefrontal cortex (PFC) integrates incoming information to guide our actions. When motivation for food-seeking competes with avoidance of danger, the PFC likely plays a role in selecting the optimal choice. In platform-mediated active avoidance, rats
Maria M Diehl +6 more
doaj +1 more source
Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans [PDF]
Front. Neural Circuits, 24 March 2014, 2013 A fundamental goal of systems neuroscience is to probe the dynamics of neural activity that drive behavior. Here we present an instrument to simultaneously manipulate neural activity via Channelrhodopsin, monitor neural response via GCaMP3, and observe behavior in freely moving C. elegans.
arxiv +1 more source
Frontiers in Cellular Neuroscience, 2019 Neuronal activity is thought to drive the remodeling of circuits in the mammalian cerebral cortex. However, its precise function in the underlying formation and elimination of glutamatergic synapses has remained controversial.
Dylan P. Quinn +6 more
doaj +1 more source
Utility of red‐light ultrafast optogenetic stimulation of the auditory pathway
EMBO Molecular Medicine, 2021 Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future alternative to electrical stimulation used in current cochlear implants. Here, we employed fast and very fast variants of the red‐light‐activated channelrhodopsin (ChR)
Burak Bali +6 more
doaj +1 more source
Ctrax extensions for tracking in difficult lighting conditions [PDF]
Scientific Reports 5 (2015), 10432, 2014 The fly tracking software Ctrax by Branson et al. is popular for positional tracking of animals both within and beyond the fly community. Ctrax was not designed to handle tracking in difficult lighting conditions with strong shadows or recurring "on"/"off" changes in lighting - a condition that will likely become increasingly common due to the advent ...
arxiv +1 more source
Scientific Reports, 2021 Ion channel proteins are physiologically important molecules in living organisms. Their molecular functions have been investigated using electrophysiological methods, which enable quantitative, precise and advanced measurements and thus require complex ...
C. Kikuchi +5 more
semanticscholar +1 more source
Practical considerations in an era of multicolor optogenetics
Frontiers in Cellular Neuroscience, 2023 The ability to control synaptic communication is indispensable to modern neuroscience. Until recently, only single-pathway manipulations were possible due to limited availability of opsins activated by distinct wavelengths.
Daniel J. Rindner, Gyorgy Lur
doaj +1 more source
Machine learning-guided channelrhodopsin engineering enables minimally-invasive optogenetics
Nature Methods, 2019 We engineered light-gated channelrhodopsins (ChRs) whose current strength and light sensitivity enable minimally invasive neuronal circuit interrogation. Current ChR tools applied to the mammalian brain require intracranial surgery for transgene delivery
C. N. Bedbrook +5 more
semanticscholar +1 more source