Results 61 to 70 of about 18,484 (195)

Spatiotemporal Control of GPR37 Signaling and Its Behavioral Effects by Optogenetics

Frontiers in Molecular Neuroscience, 2018
Despite the progress in deorphanization of G Protein-Coupled Receptors (GPCRs), ≈100 GPCRs are still classified as orphan receptors without identified endogenous ligands and with unknown physiological functions.
Wu Zheng, Wu Zheng, Jianhong Zhou, Jianhong Zhou, Yanan Luan, Jianglan Yang, Yuanyuan Ge, Muran Wang, Beibei Wu, Zhongnan Wu, Xingjun Chen, Xingjun Chen, Fei Li, Zhihui Li, Zhihui Li, Sergii Vakal, Wei Guo, Wei Guo, Jiang-Fan Chen, Jiang-Fan Chen, Jiang-Fan Chen   +20 more
doaj   +1 more source

The clinical potential of optogenetic interrogation of pathogenesis

Clinical and Translational Medicine, 2023
Background Opsin‐based optogenetics has emerged as a powerful biomedical tool using light to control protein conformation. Such capacity has been initially demonstrated to control ion flow across the cell membrane, enabling precise control of action ...
Tianyu Terry Gao, Teak‐Jung Oh, Kritika Mehta, Yu‐En Andrew Huang, Tyler Camp, Huaxun Fan, Jeong Won Han, Collin Michael Barnes, Kai Zhang   +8 more
doaj   +1 more source

Computational modeling of distinct neocortical oscillations driven by cell-type selective optogenetic drive: Separable resonant circuits controlled by low-threshold spiking and fast-spiking interneurons

Frontiers in Human Neuroscience, 2010
Selective optogenetic drive of fast spiking interneurons (FS) leads to enhanced local field potential (LFP) power across the traditional gamma frequency band (20-80Hz; Cardin et al., 2009).
Dorea Vierling-Claassen, Dorea Vierling-Claassen, Jessica Cardin, Christopher I Moore, Stephanie R Jones   +4 more
doaj   +1 more source

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications

Advanced Healthcare Materials, EarlyView.
This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin, Sean P. Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D. Howes   +6 more
wiley   +1 more source

The two-photon reversible reaction of the bistable jumping spider rhodopsin-1 [PDF]

, 2019
Bistable opsins are photopigments expressed in both invertebrates and vertebrates. These light-sensitive G-protein-coupled receptors undergo a reversible reaction upon illumination.
Deupi, Xavier, Ehrenberg, David, Heberle, Joachim, Koyanagi, Mitsumasa, Lesca, Elena, Schertler, Gebhard F. X., Terakita, Akihisa, Varma, Niranjan   +7 more
core   +1 more source

The Effects of Repetitive Use and Pathological Remodeling on Channelrhodopsin Function in Cardiomyocytes

Frontiers in Physiology, 2021
Aim: Channelrhodopsins (ChRs) are a large family of light-gated ion channels with distinct properties, which is of great importance in the selection of a ChR variant for a given application.
Balázs Ördög, A. Teplenin, T. De Coster, C. Bart, S. O. Dekker, Juan Zhang, D. Ypey, A. D. de Vries, D. Pijnappels   +8 more
semanticscholar   +1 more source

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

Advanced Materials, EarlyView.
Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll, Marc‐Joseph Antonini, Taylor M. Cannon, Pema Maretich, Greatness Olaitan, Valerie Doan Phi Van, Keisuke Nagao, Atharva Sahasrabudhe, Emmanuel Vargas Paniagua, Ethan J. Frey, Ye Ji Kim, Sydney Hunt, Melissa Hummel, Sanju Mupparaju, Alan Jasanoff, B. Jill Venton, Polina Anikeeva   +16 more
wiley   +1 more source

Optogenetic control of genetically-targeted pyramidal neuron activity in prefrontal cortex [PDF]

, 2012
A salient feature of prefrontal cortex organization is the vast diversity of cell types that support the temporal integration of events required for sculpting future responses. A major obstacle in understanding the
Donald Cooper, Donald Cooper, Matthew Pomrenze, Michael Baratta, Peter Dobelis, Samuel Dolzani, Shinya Nakamura   +6 more
core   +4 more sources

Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems

Advanced Materials, EarlyView.
This article summarizes significant technological advancements in materials, photonic devices, and bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, and on‐skin health monitoring.
Seunghyeb Ban, Hoon Yi, Jaejin Park, Yunuo Huang, Ki Jun Yu, Woon‐Hong Yeo   +5 more
wiley   +1 more source

A history of optogenetics: the development of tools for controlling brain circuits with light [PDF]

, 2011
Understanding how different kinds of neuron in the brain work together to implement sensations, feelings, thoughts, and movements, and how deficits in specific kinds of neuron result in brain diseases, has long been a priority in basic and clinical ...
Boyden, Edward Stuart
core   +2 more sources