Results 81 to 90 of about 18,335 (296)

In Utero Electroporation for Manipulation of Specific Neuronal Populations

open access: yesMembranes, 2022
The complexity of brain functions is supported by the heterogeneity of brain tissue and millisecond-scale information processing. Understanding how complex neural circuits control animal behavior requires the precise manipulation of specific neuronal ...
Kotaro Yamashiro   +2 more
doaj   +1 more source

Precise excitation-inhibition balance controls gain and timing in the hippocampus

open access: yeseLife, 2019
Excitation-inhibition (EI) balance controls excitability, dynamic range, and input gating in many brain circuits. Subsets of synaptic input can be selected or 'gated' by precise modulation of finely tuned EI balance, but assessing the granularity of EI ...
Aanchal Bhatia   +2 more
doaj   +1 more source

Finite-State Channel Models for Signal Transduction in Neural Systems

open access: yes, 2016
Information theory provides powerful tools for understanding communication systems. This analysis can be applied to intercellular signal transduction, which is a means of chemical communication among cells and microbes.
Eckford, Andrew W.   +2 more
core   +1 more source

Optogenetic perturbations reveal the dynamics of an oculomotor integrator [PDF]

open access: yes, 2014
Many neural systems can store short-term information in persistently firing neurons. Such persistent activity is believed to be maintained by recurrent feedback among neurons.
Arrenberg, AB   +4 more
core   +1 more source

Computational modeling of distinct neocortical oscillations driven by cell-type selective optogenetic drive: Separable resonant circuits controlled by low-threshold spiking and fast-spiking interneurons

open access: yesFrontiers in Human Neuroscience, 2010
Selective optogenetic drive of fast spiking interneurons (FS) leads to enhanced local field potential (LFP) power across the traditional gamma frequency band (20-80Hz; Cardin et al., 2009).
Dorea Vierling-Claassen   +4 more
doaj   +1 more source

Crystal structure of the red light-activated channelrhodopsin Chrimson

open access: yesNature Communications, 2018
Channelrhodopsins are light-activated ion channels that mediate cation permeation across cell membranes upon light absorption. Red-light-activated channelrhodopsins are of particular interest, because red light penetrates deeper into biological tissues ...
K. Oda   +9 more
semanticscholar   +1 more source

Functional Studies of Volvox Channelrhodopsin Chimeras [PDF]

open access: yesBiophysical Journal, 2010
Recently, two new members of the channelrhodopsin family have been discovered in the multicellular green alga Volvox carteri and named VChR1 and VChR2. VChR2 shows a similar characteristic to the known Chlamydomonas ChR2 [1], which is successfully employed in optogenetics.
Satoshi P. Tsunoda   +3 more
openaire   +2 more sources

Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling

open access: yesNature Communications, 2022
AbstractChannelrhodopsins are light-gated ion channels used to control excitability of designated cells in large networks with high spatiotemporal resolution. While ChRs selective for H+, Na+, K+ and anions have been discovered or engineered, Ca2+-selective ChRs have not been reported to date. Here, we analyse ChRs and mutant derivatives with regard to
Rodrigo G. Fernandez Lahore   +12 more
openaire   +5 more sources

Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo

open access: yesAdvanced Materials, EarlyView.
Convergence drawing is used to create flexible, microscale, multifunctional fiber‐based neural probes. Optimized materials selection enables individual devices to perform neural recording, electrical stimulation, optogenetics, fiber photometry, fluid delivery, and voltammetric neurotransmitter detection in rodents.
Nicolette Driscoll   +16 more
wiley   +1 more source

Vectorial Ion Transport by Channelrhodopsin-2 [PDF]

open access: yesBiophysical Journal, 2009
Channelrhodopsins represent a third member of microbial-type rhodopsins and have gained considerable attention in neurobiology as a tool to control the excitability of neurons. The other photoreceptors act either as light-driven ion pumps like bacteriorhodopsin (BR) or as part of a relay system like the sensory rhodopsins (SR).
Christian Bamann   +3 more
openaire   +2 more sources

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