Results 81 to 90 of about 18,484 (195)

Machine learning-guided directed evolution for protein engineering [PDF]

, 2019
Machine learning (ML)-guided directed evolution is a new paradigm for biological design that enables optimization of complex functions. ML methods use data to predict how sequence maps to function without requiring a detailed model of the underlying ...
Arnold, Frances H., Wu, Zachary, Yang, Kevin K.   +2 more
core   +1 more source

Allatostatin-A neurons inhibit feeding behavior in adult Drosophila [PDF]

, 2012
How the brain translates changes in internal metabolic state or perceived food quality into alterations in feeding behavior remains poorly understood.
Anderson, David J., Hergarden, Anne Christina, Tayler, Timothy D.   +2 more
core   +2 more sources

Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron‐Mediated Lung‐to‐Brain Axis

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSC) are considered a promising alternative for neuropathic pain (NP) treatment, but underlying mechanisms remain elusive. Huang et al. illustrate that a Npy2r sensory neuron‐related lung–brain axis contributes to MSC analgesia.
Jing Huang, Taihe Zhou, Yueming Sun, Yuanchen Ma, Yiwen Deng, Keyu Chen, Ruijie Li, Yuan Qiu, Tao Wang, Xiaoyong Chen, Li Huang, Lu Zhu, Xueyi Tu, Ying Wang, Zheming Liu, Rouchen Lin, Yunli Tong, Yuantao Li, Heshe Li, Lin Nie, Rui Fang, Jianqi Feng, Xuhong Wei, Xia Feng, Andy Peng Xiang, Xiaoran Zhang   +25 more
wiley   +1 more source

wavelength dependent photoreactions induced by ground-state heterogeneity [PDF]

, 2015
The primary photodynamics of channelrhodopsin-1 from Chlamydomonas augustae (CaChR1) was investigated by VIS-pump supercontinuum probe experiments from femtoseconds to 100 picoseconds.
Heberle, Joachim, Heyne, Karsten, Muders, Vera, Schlesinger, Ramona, Stensitzki, Till   +4 more
core   +1 more source

Neuronal Endothelin a Receptor Mediates Experimental and Clinical Vascular Pain through an Endothelial‐Neural Axis

Advanced Science, EarlyView.
The authors develop mouse models by mimicking peripheral vascular diseases, combining multiple strategies and transgenic mouse lines, to demonstrate that ECs, but not macrophages or SMCs, play an active role mediated by endothelial ET‐1/neural ETAR signaling and beyond endothelial homeostatic angiocrine by driving protective pain through the ...
Zuo‐Jie Jiang, Di Mu, Su Liu, Peng‐Bo Jing, Bin Wu, Xiao‐Mei Yang, Jia‐Yi Ge, Qing‐Yi Li, Hao‐Hao Chen, Feng‐Ming Zhang, Bing Wang, Ying‐Ying Zhang, Linnan Qian, Zi‐Yi Zhu, Yu‐Sen Ou, Shi‐Yu Sun, Lin Luo, Yu Feng, Changyu Jiang, Zhuo Sun, Yong Chen, Hai‐Li Pan, Bin Wang, Fen‐Fei Gao, Jie Wu, Zhigang Lu, Tong Liu, Yan‐Gang Sun, Xing‐Jun Liu   +28 more
wiley   +1 more source

An inhibitory pull-push circuit in frontal cortex. [PDF]

, 2017
Push-pull is a canonical computation of excitatory cortical circuits. By contrast, we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP)-expressing interneurons.
AA Zekveld, CK Pfeffer, CM Niell, D Huber, Dario L Ringach, DS Greenberg, Elaine Tring, HJ Pi, I Ozden, JJ Letzkus, Joshua T Trachtenberg, JS Anderson, L Petreanu, M Vinck, MJ McGinley, MM Karnani, Pablo Garcia-Junco-Clemente, PJ Mineault, PO Polack, RB Ebitz, RJ Douglas, S Lee, SL Smith, Taruna Ikrar, TW Chen, Xiangmin Xu, Y Fu   +26 more
core   +1 more source

Optogenetic dissection of amygdala functioning

Frontiers in Behavioral Neuroscience, 2014
Studies of amygdala functioning have occupied a significant place in the history of understanding how the brain controls behavior and cognition. Early work on the amygdala placed this small structure as a key component in the regulation of emotion and ...
Ryan eLalumiere
doaj   +1 more source

Novel Cerebello-Amygdala Connections Provide Missing Link Between Cerebellum and Limbic System

Frontiers in Systems Neuroscience, 2022
The cerebellum is emerging as a powerful regulator of cognitive and affective processing and memory in both humans and animals and has been implicated in affective disorders. How the cerebellum supports affective function remains poorly understood.
Se Jung Jung, Ksenia Vlasov, Alexa F. D’Ambra, Abhijna Parigi, Mihir Baya, Edbertt Paul Frez, Jacqueline Villalobos, Marina Fernandez-Frentzel, Maribel Anguiano, Yoichiro Ideguchi, Evan G. Antzoulatos, Evan G. Antzoulatos, Diasynou Fioravante, Diasynou Fioravante   +13 more
doaj   +1 more source

Cutting‐Edge Advancements in Physical Stimulation for Spiral Ganglion Neuron Protection and Regeneration

Advanced NanoBiomed Research, EarlyView.
Physical stimulation strategies have emerged as a therapeutic avenue for the regeneration of spiral ganglion neurons. This review explores diverse physical stimulation modalities—including topographical modulation, electrical stimulation, and photostimulation—each operating through distinct mechanisms to regulate SGN biological behavior. By elucidating
Yuhan Bai, Bin Zhang, Hong Cheng, Yunzhu Huang, Xinyue Han, Yangnan Hu, Renjie Chai, Wei Cao   +7 more
wiley   +1 more source

Computational Modeling of Channelrhodopsin-2 Photocurrent Characteristics in Relation to Neural Signaling

, 2013
Channelrhodopsins-2 (ChR2) are a class of light sensitive proteins that offer the ability to use light stimulation to regulate neural activity with millisecond precision.
Khargonekar, Pramod P., Shivakeshavan, R. G., Stefanescu, Roxana A., Talathi, Sachin S.   +3 more
core   +1 more source