Results 61 to 70 of about 13,731 (261)

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

open access: yesAdvanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai   +12 more
wiley   +1 more source

Optimal Performance and Application for Firework Algorithm Using a Novel Chaotic Approach

open access: yesIEEE Access, 2020
Aimed at the bottleneck of Firework Algorithm's performance and the problem that it is easy to fall into the local extremum, this paper introduces a chaotic map approach and analyzes its statistical characteristics.
Weilin Luo   +4 more
doaj   +1 more source

Encoding Cumulation to Learn Perturbative Nonlinear Oscillatory Dynamics

open access: yesAdvanced Science, EarlyView.
Weak nonlinearities critically shape the long term behavior of oscillatory systems but are difficult to identify from data. A data‐driven framework is introduced to infer governing equations of weakly nonlinear oscillators from sparse and noisy observations.
Teng Ma   +5 more
wiley   +1 more source

Development and application of new 2D Cubic-Sine hyperchaotic map

open access: yesCybersecurity
Recently, chaotic maps possessing favorable chaotic properties have been extensively utilized in cryptography. One-dimensional (1D) chaotic maps, owing to their limited chaotic complexity, are not suitable for high-security requirements. Two-dimensional (
Wanqing Wu, Jipeng Zhou
doaj   +1 more source

General Construction Method and Proof for a Class of Quadratic Chaotic Mappings

open access: yesMathematics
The importance of chaotic systems as the main pseudo-random cryptographic generator of encryption algorithms in the field of communication secrecy cannot be overstated, but in practical applications, researchers often choose to build upon traditional ...
Wenxia Xu   +4 more
doaj   +1 more source

Chaos in Duopoly Games via Furstenberg Family Couple

open access: yesComplexity, 2019
Assume that H1 and H2 are two given closed subintervals of ℝ and that f2:H1⟶H2 and f1:H2⟶H1 are continuous maps. Let ϒh1,h2=f1h2,f2h1 be a Cournot map over the space H1×H2. In this paper, we study G1,G2-chaos (resp.
Yu Zhao, Risong Li
doaj   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu   +9 more
wiley   +1 more source

SpatialESD: Spatial Ensemble Domain Detection in Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
ABSTRACT Spatial transcriptomics (ST) measures gene expression while preserving spatial context within tissues. One of the key tasks in ST analysis is spatial domain detection, which remains challenging due to the complex structure of ST data and the varying performance of individual clustering methods. To address this, we propose SpatialESD, a Spatial
Hongyan Cao   +11 more
wiley   +1 more source

Chemically Engineered L. reuteri Delivering αPD‐L1 and Gallium Ions via Metal‐Phenolic Networks Potentiate Anti‐Tumor Immunity and Ferroptosis

open access: yesAdvanced Science, EarlyView.
A multifaceted chemical strategy, integrating bacterial tropism, metal‐ion interference therapy, and immunotherapy, resulted in significant tumor regression in murine models. A pioneering paradigm for the design of biohybrid materials was established, highlighting how sophisticated chemical engineering of living systems can unlock new avenues for ...
Tingting Zhang   +7 more
wiley   +1 more source

Kinesin‐Induced Buckling Reveals the Limits of Microtubule Self‐Repair

open access: yesAdvanced Science, EarlyView.
This study shows that kinesin‐driven buckling induces extensive microtubule lattice damage that often exceeds intrinsic self‐repair and leads to filament failure. While curvature, motor motility, and force individually cause limited damage, their combination overwhelms repair.
Shweta Nandakumar   +9 more
wiley   +1 more source

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