Results 231 to 240 of about 226,086 (342)

Parkinson's‐Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa

Movement Disorders, EarlyView.
Abstract Background Peripheral disease mechanisms such as immune dysregulation may contribute to Parkinson's disease (PD). To investigate interactions between common PD mutations and immune responses to environmental pathogens, we studied responses to Pseudomonas aeruginosa (P.
Julian R. Mark, Hannah A. Staley, Ann M. Titus, Julian Agin‐Liebes, Alicia Garrido, Laura Hughes, Nicolas Dzamko, Rebecca L. Wallings, Malú Gámez Tansey   +8 more
wiley   +1 more source

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteins

EMBO Journal, 2016
Sarah N. Fontaine, D. Zheng, Jonathan J. Sabbagh, Mackenzie D. Martin, Dale Chaput, April L Darling, J. Trotter, Andrew R. Stothert, B. Nordhues, A. Lussier, Jeremy D. Baker, Lindsey B. Shelton, M. Kahn, Laura J. Blair, S. Stevens, C. Dickey   +15 more
semanticscholar   +1 more source

Nuclear Alpha‐Synuclein: Mechanisms and Implications for Synucleinopathies

Movement Disorders, EarlyView.
Abstract Alpha‐synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson's disease (PD) and related synucleinopathies. Recent advances reveal that aSyn dynamically localizes to neuronal nuclei in both health and disease ...
Tiago Fleming Outeiro, David J. Koss
wiley   +1 more source

Differences in the chaperone-like activities of the four main small heat shock proteins of Drosophila melanogaster

, 2006
Geneviève Morrow, John J. Heikkila, Robert M. Tanguay   +2 more
openalex   +1 more source

Uncovering the Complexity of Synucleinopathies: An Ongoing Tale Between Proteins and Lipids

Movement Disorders, EarlyView.
Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson's disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies and Lewy neurites.
Manuel Flores‐León, Tiago F. Outeiro
wiley   +1 more source

G4 Oligonucleotide-Based Chaperones of Heterogeneous Nuclear Ribonucleoprotein A1. [PDF]

Int J Mol Sci
Malakhova E, Svetlova J, Pavlova I, Alieva S, Severov V, Barinov N, Klinov D, Vedekhina T, Varizhuk A.   +8 more
europepmc   +1 more source

The Hsp90 Co-Chaperone Sgt1 Governs Candida albicans Morphogenesis and Drug Resistance

, 2012
Rebecca S. Shapiro, Aimee K. Zaas, Marisol Betancourt-Quiroz, John R. Perfect, Leah E. Cowen   +4 more
openalex   +2 more sources

A New Glucocerebrosidase Chaperone Reduces α-Synuclein and Glycolipid Levels in iPSC-Derived Dopaminergic Neurons from Patients with Gaucher Disease and Parkinsonism

Journal of Neuroscience, 2016
E. Aflaki, Daniel K. Borger, Nima Moaven, B. Stubblefield, S. Rogers, S. Patnaik, F. Schoenen, W. Westbroek, Wei Zheng, Patricia Sullivan, H. Fujiwara, Rohini Sidhu, Zayd M. Khaliq, G. Lopez, D. Goldstein, D. Ory, J. Marugan, E. Sidransky   +17 more
semanticscholar   +1 more source

The Race to Salvage Glucocerebrosidase: Understanding Small‐Molecule Therapies for GBA1‐Associated Parkinsonism

Movement Disorders, EarlyView.
Variants in GBA1, the gene encoding the lysosomal enzyme glucocerebrosidase, cause Gaucher disease and confer an increased risk for parkinsonism. Strategies using small molecules can improve the function of glucocerebrosidase in lysosomes. A clear understanding of the mechanism‐of‐action of these compounds will facilitate development of GBA1‐modulating
Mark J. Henderson, Tiffany C. Chen, Logan M. Glasstetter, Yu Chen, Juan J. Marugan, Ellen Sidransky   +5 more
wiley   +1 more source

The low complexity linker of DNAJB6b is key to its anti-amyloid function. [PDF]

QRB Discov
Merkelis T, Olsson U, Linse S.
europepmc   +1 more source