Results 211 to 220 of about 287,054 (305)

NAD⁺ restores proteostasis through splicing-dependent autophagy. [PDF]

Autophagy
Ai R, Fang EF.
europepmc   +1 more source

Conditional Modeling of GNAO1 Disorder Dissociates Circuit Specific Contributions to Pathology and Rationalizes Ameliorative Strategies

Movement Disorders, EarlyView.
Abstract Background Neurodevelopmental disorders feature various symptoms that frequently include seizures and motor manifestations, but their attribution to disruptions of specific circuits and molecular alterations is notoriously hard to establish, which limits therapeutic interventions.
Gloria Brunori, Stefano Zucca, Colten K. Lankford, Yi‐Zhi Wang, Marianna Franco, Nina A. Alekseeva, Sevinj Ahmedova, Han My Van, Jeffrey N. Savas, Kirill A. Martemyanov   +9 more
wiley   +1 more source

Stress-Driven Selective Neuronal Vulnerability in Charcot-Marie-Tooth Disease: From Prodromal Pathology to Therapeutic Implications. [PDF]

Cells
Pan X, Xie J, Li Z, Xiang Y, Yu Y, Cai Q, Xu H, Wan Y, Xing J.   +8 more
europepmc   +1 more source

Regulation of AP1 adaptor assembly by the bi-handed chaperone MEA1. [PDF]

Nat Commun
Wan C, Wu J, Ouyang Y, Puscher H, Tian Y, Li S, Yin Q, Shen J.   +7 more
europepmc   +1 more source

Lithium chloride corrects weakness and myopathology in a preclinical model of LGMD1D [PDF]

, 2019
Bengoechea, Rocio, Chou, Tsui-Fen, Findlay, Andrew R., Pittman, Sara K., True, Heather L., Weihl, Conrad C.   +5 more
core   +1 more source

Deciphering the soybean root rot pathogen Phytophthora sojae: Signaling pathways, transcriptional regulation, and effector biology

New Plant Protection, EarlyView.
This review highlights how Phytophthora sojae utilizes unconventional lineage‐specific signaling networks, including unique G protein‐coupled receptor fusions, expanded kinases, and rapidly evolving effectors, to infect soybeans. Understanding these divergent molecular paradigms reveals critical vulnerabilities in this destructive pathogen, offering ...
Min Qiu, Xiaoyi Zhang, Bo Yang, Wenwu Ye, Yuanchao Wang   +4 more
wiley   +1 more source

Model Peptides Enable Comparisons of Substrate Binding Modes of Hsp70 Molecular Chaperones. [PDF]

Biochemistry
Bhasne K, Dörries L, Maqtedar A, Mager ST, Clerico EM, Gierasch LM.   +5 more
europepmc   +1 more source

Endoplasmic reticulum stress and the unfolded protein response in lung diseases: molecular pathways and therapeutic interventions

The Journal of Pathology, EarlyView.
Abstract Endoplasmic reticulum stress (ERS) occurs when the protein‐folding capacity of the endoplasmic reticulum (ER) is overwhelmed, triggering the unfolded protein response (UPR) to restore homeostasis. However, severe or persistent ERS can shift the UPR toward pro‐inflammatory, apoptotic, and fibrotic signaling, thereby exacerbating tissue injury ...
Lanlan Song, Yichen Liu, Chen Xu, Yaochen Zhang, Kaiming Xu, Dan Yao, Xiaoying Huang   +6 more
wiley   +1 more source

Regulatory role of serine 59 in the oligomeric dynamics and chaperone function of αB-crystallin. [PDF]

Sci Rep
Tender T, Santhoshkumar P, Suleiman L, Hoq MR, Sharma KK.   +4 more
europepmc   +1 more source

Proteomic Changes in Cancer Cell Lines as a Result of Bacterial Infection

PROTEOMICS, EarlyView.
ABSTRACT Bacterial infections have been implicated in shaping the tumor microenvironment (TME), but their effects on cancer cell proteomes remain unexplored. In this study, we analyzed proteomic changes in melanoma (A375) and ovarian cancer (OVCAR3) cell line models following infection with Staphylococcus aureus strain USA300 or Salmonella enterica ...
Bo Ren, Kenneth Weke, Darryl Hardie, Mariya I. Goncheva, Ted Hupp, Javier Antonio Alfaro, Helena Pětrošová, David R. Goodlett   +7 more
wiley   +1 more source