Results 201 to 210 of about 196,418 (255)

Viscoelastic hydrogel potentiates cancer cell stemness and drug resistance through Piezo1‐dependent mechanotransduction

BMEMat, EarlyView.
The effects of matrix dynamics on cancer progression remain unclear. Herein, we fabricated a tunable dynamic hydrogel via reversible host–guest crosslinking and demonstrated that high matrix dynamics activate Piezo1 and its downstream PI3K/AKT and Wnt/β‐catenin signaling pathways, thereby enhancing cancer spheroid assembly, elevating cancer stemness ...
Yi Liu, Huiyao Deng, Hanlei Zhang, Chutian Huang, Huolun Feng, Xiayi Xu, Heemin Kang, Meiling Zhu, Liming Bian, Kunyu Zhang   +9 more
wiley   +1 more source

CISP, an Intrinsically Disordered Cold-Inducible Barley Protein, Functions as a Small RNA Chaperone. [PDF]

Plant Direct
Okumura Y, Haque MM, Kidou SI.
europepmc   +1 more source

Crystallographic analysis of the Sec-dependent secretion chaperone CsaA. [PDF]

, 2007
Shapova, Yuliya
core  

Enzymatic Electrosynthesis for Sustainable CO2 Conversion: Advancing Circular Carbon Economy

Carbon Energy, EarlyView.
Enzymatic electrosynthesis (EES) offers molecular precision in synthesizing value‐added products from CO2. We highlight its distinct edge over alternative enzyme‐hybrid systems and analyze electron transfer pathways. Key strategies to overcome electron transfer bottlenecks and expand product diversity are addressed, and also data‐driven approaches for ...
Yan Xie, Jia Ouyang, Manu Suvarna, Xiangzhou Yuan, Matthew R. Hill, Uwe Bornscheuer, Huiyan Zhang, Yong Sik Ok   +7 more
wiley   +1 more source

The N-terminal domain of the endoplasmic reticulum-resident chaperone Grp94 functions in aggregation prevention. [PDF]

J Biol Chem
Adedeji A, Unruh E, Derr A, Ndolo C, Balch M, Paul K, Morton AJ, Kravats AN.   +7 more
europepmc   +1 more source

Infrared Laser Heating Reveals a Reversible Phase Transition of Phosphofructokinase 1 in Mammalian Cells

Chemistry – A European Journal, EarlyView.
In this study, we present a novel method to investigate the phase behavior of biomolecular condensates in living cells. The method complements FRAP experiments, expanding the existing toolbox for characterization of condensates within living cells. ABSTRACT Metabolic enzymes can operate in concerted networks, so‐called metabolons.
Morten Mosbach, Sneha Pavanan Kuruvanthara, Lukas Johannknecht, Simon Ebbinghaus   +3 more
wiley   +1 more source

Reconstitution of glycan-driven MHC-I recycling reveals calreticulin as mediator between TAPBPR and tapasin. [PDF]

EMBO J
Heinke TJ, Fahim A, Popovic N, Rath T, Müller IK, Morgner N, Trowitzsch S, Tampé R.   +7 more
europepmc   +1 more source

Getting the Big Ones to Pack: Crystal Structure of Vitamin K2 With a Chaperone

Chemistry – A European Journal, EarlyView.
A method for obtaining co‐crystals of medium‐size organic molecules and ‐tetrakis(2‐fluoro‐4‐methoxyphenyl)adamantane (TFM) as chaperone was developed. This method yielded a high‐resolution x‐ray crystal structure of menaquinone MK‐4 (vitamin K2), in which layers of chaperone and vitamin guest molecules are found.
Jan Hartenfels, Greta Lília Runge‐Seither, Tim Berking, Johanna Osterbrink, Carsten Wolf, Clemens Richert   +5 more
wiley   +1 more source

Beyond Inhibition: Rebalancing the Hsp90 Chaperone Network as a Therapeutic Strategy for Alzheimer's Disease. [PDF]

Drug Des Devel Ther
Tang Z, Xie H, Xu Y, Zhou Z, Lu F, Wu Q, Liang W, Zhong M, Li S.   +8 more
europepmc   +1 more source

Expression, Purification, and Microscopy‐Based Assays for Engineered Recombinant Tyrosinated, Detyrosinated, and Δ2 Human Tubulin

Cytoskeleton, EarlyView.
ABSTRACT Microtubules are noncovalent polymers assembled from α/β tubulin dimers. Their structure, dynamics and interaction with effectors are regulated through the expression of diverse tubulin isotypes and chemically diverse posttranslational modifications, also known as the “tubulin code.” Understanding the biophysical correlates between tubulin ...
Jiayi Chen, Agnieska Szyk, Antonina Roll‐Mecak   +2 more
wiley   +1 more source