The Chaperonin TRiC/CCT Inhibitor HSF1A Protects Cells from Intoxication with Pertussis Toxin
ToxinsPertussis toxin (PT) is a bacterial AB5-toxin produced by Bordetella pertussis and a major molecular determinant of pertussis, also known as whooping cough, a highly contagious respiratory disease.
Jinfang Jia +4 more
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Versatile platform for nanotechnology based on circular permutations of chaperonin protein [PDF]
, 2010 The present invention provides chaperonin polypeptides which are modified to include N-terminal and C-terminal ends that are relocated from the central pore region to various different positions in the polypeptide which are located on the exterior of the
Chan, Suzanne L. +5 more
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The Differences Between Products Of Gene Expression In Male, Female And Hermaphrodite Cucumber Floral Buds (Cucumis Sativus L.) [PDF]
, 2011 Cucumber is a species in which sex expression has been extensively studied. Sexual differentiation is controlled by genotypic and environmental factors.
Ewa Siedlecka +2 more
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Hetero-oligomeric CPN60 resembles highly symmetric group I chaperonin structure revealed by Cryo-EM
bioRxiv, 2018 The chloroplast chaperonin system is indispensable for the biogenesis of Rubisco, the key enzyme in photosynthesis. Using Chlamydomonas reinhardtii as the model system, we revealed that chloroplast chaperonin is consisted of CPN60α, CPN60β1, and CPN60β2,
Qian Zhao +7 more
semanticscholar +1 more source
Development of a multigenic metabarcoding of prokaryotic microbiota: application to Bacteria and Archaea of agronomical interest encountered in the rice rhizosphere of Camargue [PDF]
, 2017 It is our hypothesis that soil and plant microbiota are playing an eminent role in shaping both natural ecosystems and agricultural production systems. It is now widely admitted that bacterial communities show a great diversity in the rhizosphere and in ...
Blondin, Laurence +3 more
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RNA interference approaches for treatment of HIV-1 infection. [PDF]
, 2015 HIV/AIDS is a chronic and debilitating disease that cannot be cured with current antiretroviral drugs. While combinatorial antiretroviral therapy (cART) can potently suppress HIV-1 replication and delay the onset of AIDS, viral mutagenesis often leads to
Bobbin, Maggie L +2 more
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Protein folding tames chaos [PDF]
, 2013 Protein folding produces characteristic and functional three-dimensional structures from unfolded polypeptides or disordered coils. The emergence of extraordinary complexity in the protein folding process poses astonishing challenges to theoretical ...
Wei, Guo-Wei, Xia, Kelin
core
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Glucosylation of host proteins is a common pathogenicity mechanism of bacterial protein toxins. Prominent examples are Clostridium difficile toxins A and B, which inactivate Rho proteins by glucosylation and cause diarrhea and ...
Marcus Steinemann +3 more
semanticscholar +1 more source
Chaperonin–Dendrimer Conjugates for siRNA Delivery
Advancement of science, 2016 The group II chaperonin thermosome (THS) is a hollow protein nanoparticle that can encapsulate macromolecular guests. Two large pores grant access to the interior of the protein cage.
Martin G. Nussbaumer +5 more
semanticscholar +1 more source
Heat shock proteins and oral diseases
SRM Journal of Research in Dental Sciences, 2012 Heat shock proteins (HSPs) are substances expressed in response to elevated temperatures or other cellular stress. They are highly conserved proteins inhabiting nearly all subcellular compartments and are found in all organisms and all cell types. When a
G Suresh Babu +3 more
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