Results 1 to 10 of about 15,047 (183)
Phage Display Selection and In Silico Characterization of Peptides as Potential GroEL Modulators [PDF]
PharmaceuticsBackground/Objectives. Antibiotic resistance is an escalating global health concern, highlighting the need for innovative antibacterial strategies beyond traditional drugs.
Stefania Olla +4 more
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GroEL/ES chaperonin unfolds then encapsulates a nascent protein on the ribosome [PDF]
Nature CommunicationsThe bacterial chaperonin GroEL/ES promotes protein folding post-translation by transiently encapsulating client proteins within a central chamber. GroEL also binds translating ribosomes in vivo, implying an additional role in cotranslational folding ...
Alžběta Roeselová +7 more
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Analysis of peptides and proteins in their binding to GroEL [PDF]
Journal of Peptide Science, 2010 AbstractThe GroEL–GroES is an essential molecular chaperon system that assists protein folding in cell. Binding of various substrate proteins to GroEL is one of the key aspects in GroEL‐assisted protein folding. Small peptides may mimic segments of the substrate proteins in contact with GroEL and allow detailed structural analysis of the interactions ...
Yali Li
exaly +3 more sources
GroEL/ES inhibitors as potential antibiotics [PDF]
Bioorganic and Medicinal Chemistry Letters, 2016 We recently reported results from a high-throughput screening effort that identified 235 inhibitors of the Escherichia coli GroEL/ES chaperonin system [Bioorg. Med. Chem. Lett.2014, 24, 786]. As the GroEL/ES chaperonin system is essential for growth under all conditions, we reasoned that targeting GroEL/ES with small molecule inhibitors could be a ...
Andrew J Ambrose +2 more
exaly +3 more sources
Репродуктивная эндокринология, 2021 Research objective: in a prospective controlled study to investigate the role of HSP60, GroEl and other infertility factors as predictors of successful IVF outcome. Materials and methods.
V.O. Berestovyi +5 more
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Роль білків теплового шоку в прогнозуванні перебігу клімактеричного синдрому
Український журнал Здоров'я жінки, 2022 Проблема клімактерію актуальна вже протягом багатьох десятиліть. Патогенетично обґрунтованим методом лікування, враховуючи зміну гормонального фону жінки, є замісна гормональна терапія.
I.V. Sokol, D.O. Govsieiev
doaj +1 more source
Gut Microbes, 2021 Gut microbiota and the immune system are in constant exchange shaping both host immunity and microbial communities. Here, improper immune regulation can cause inflammatory bowel disease (IBD) and colitis. Antibody therapies blocking signaling through the
Verena Friedrich +11 more
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Probing the dynamic process of encapsulation in Escherichia coli GroEL. [PDF]
PLoS ONE, 2013 Kinetic analyses of GroE-assisted folding provide a dynamic sequence of molecular events that underlie chaperonin function. We used stopped-flow analysis of various fluorescent GroEL mutants to obtain details regarding the sequence of events that ...
Toshifumi Mizuta +4 more
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GroEL‐Mediated protein folding [PDF]
Protein Science, 1997 Abstract Architecture of GroEL and GroES and the reaction pathway Architecture of the chaperonins Reaction pathway of GroEL‐GroES‐mediated folding Polypeptide binding A parallel network of chaperones binding polypeptides in vivo Polypeptide binding in vitro Role of hydrophobicity in recognition Homologous proteins with differing recognition ...
W A, Fenton, A L, Horwich
openaire +2 more sources
Український журнал Здоров'я жінки, 2022 Жiнки клiмактеричнoгo вiку становлять 10% популяції Землі, і наразі проблема патологічного клімактерію залишається актуальною. Причиною розвитку клімактерію вважається дефіцит естрогенів, тому використання замісної терапії є патогенетично обґрунтованим ...
I.V. Sokol, D.O. Govsieiev
doaj +1 more source