Results 41 to 50 of about 18,538 (219)

GroEL is an immunodominant surface-exposed antigen of Rickettsia typhi

PLoS ONE, 2021
Rickettsioses are neglected and emerging potentially fatal febrile diseases that are caused by obligate intracellular bacteria, rickettsiae. Rickettsia (R.) typhi and R.
Jessica Rauch, Jessica Barton, Marcel Kwiatkowski, Malte Wunderlich, Pascal Steffen, Kristin Moderzynski, Stefanie Papp, Katharina Höhn, Hella Schwanke, Susanne Witt, Ulricke Richardt, Ute Mehlhoop, Hartmut Schlüter, Verena Pianka, Bernhard Fleischer, Dennis Tappe, Anke Osterloh   +16 more
doaj   +2 more sources

Prediction of Unwanted Crystallization of Freeze-Dried Protein Formulations Using α-Relaxation Measurements

Pharmaceutics, 2023
There is a lack of methods to predict the isothermal crystallization behavior of amorphous freeze-dried formulations stored below the glass transition temperature. This study applies isothermal microcalorimetry to predict long-term crystallization during
Sebastian Groël, Tim Menzen, Gerhard Winter   +2 more
doaj   +1 more source

Suppression of amyloid fibrils using the GroEL apical domain [PDF]

In E. coli cells, rescue of non-native proteins and promotion of native state structure is assisted by the chaperonin GroEL. An important key to this activity lies in the structure of the apical domain of GroEL (GroEL-AD) (residue 191–376), which ...
80335504, 本郷, 邦広, 河田, 康志, 27412, 溝端, 知宏, Kawata, Yasushi, 27413, 50263489, カワタ, ヤスシ, 100000572, Ojha, Bimlesh, 1457, 100000496, 100000563, Fukui, Naoya, 2225, Mizobata, Tomohiro, 779, 40177697, Hongo, Kunihiro, ミゾバタ, トモヒロ, ホンゴウ, クニヒロ   +21 more
core   +1 more source

GroEL ring separation and exchange in the chaperonin reaction [PDF]

, 2019
The bacterial chaperonin GroEL and its cofactor GroES form a nano-cage for a single molecule of substrate protein (SP) to fold in isolation. GroEL and GroES undergo an ATP-regulated interaction cycle that governs the closing and opening of the folding ...
Yan, Xiao, Yan, X.
core   +1 more source

Allosteric differences dictate GroEL complementation of E. coli

, 2022
GroES/GroEL is the only bacterial chaperone essential under all conditions, making it a potential antibiotic target. Rationally targeting ESKAPE GroES/GroEL as an antibiotic strategy necessitates studying their structure and function.
Marty, Michael T., Johnson, Steven M., Hoang, Quyen Q., Zhang, Donna D., Stevens, Mckayla, Watson, Edmond R., Lander, Gabriel C., Ngo, Duc, Wu, Chunxiang, Zerio, Christopher J., Chapman, Eli, Kaneko, Lynn K., Park, Yangshin, Ray, Anne-Marie, Sivinski, Jared, Ambrose, Andrew J., Kostelic, Marius M.   +16 more
core   +1 more source

Probiotic Characteristics of Lactic Acid Bacteria Isolated from the Intestinal Tract of Mothers and Infants in Hotan, Xinjiang

Shipin gongye ke-ji
In this study, the lactic acid bacteria from the feces of Uygur mother-infant pairs in Hotan, Xinjiang, was isolated and identified. The bacteriostatic performance of the isolates for diarrhea pathogenic bacteria was assessed, and the probiotic ...
Jianjun LI, Gulibaikeremu·AIBIBOLA, Yongqing NI, Xu LI   +3 more
doaj   +1 more source

Heterologous expression of Brucella abortus GroEL heat-shock protein in Lactococcus lactis

Microbial Cell Factories, 2006
Background Brucella abortus is a facultative intracellular pathogen that mainly infects cattle and humans. Current vaccines rely on live attenuated strains of B.
Langella Philippe, Oliveira Sérgio C, Le Loir Yves, Ribeiro Luciana A, Bermúdez-Humarán Luis G, Miyoshi Anderson, Azevedo Vasco   +6 more
doaj   +1 more source

Субклінічне внутрішньоутробне запалення як детермінанта екстремально ранніх передчасних пологів: інтегральний аналіз системних маркерів (власне дослідження)

Український журнал Перинатологія і педіатрія
Мета - визначити прогностичну цінність клінічних, лабораторних, ультразвукових і психоемоційних маркерів у ризику розвитку екстремально ранніх передчасних пологів (ЕРПП) на тлі внутрішньоутробного інфікування. Матеріали і методи.
O.B. Yaroshchuk, D.O. Govsieiev
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Heat Stress and Gut Microbiome Dynamics in Poultry: Interplay, Consequences, and Mitigation Strategies

Animal Research and One Health, EarlyView.
Heat stress disrupts gut microbial balance in poultry, impairing nutrient absorption and immunity. This review outlines the interplay between thermal stress and microbiome dynamics and discusses integrative mitigation strategies, probiotics, phytogenics, cooling systems, and genetic adaptation to enhance poultry resilience.
O. E. Oke, A. I. Oni, O. A. Akosile, K. M. Oliyide, C. A. Ishola, M. O. Logunleko, O. A. Jimoh, C. P. Njoku, L. O. Fasasi, V. A. Uyanga   +9 more
wiley   +1 more source