Results 51 to 60 of about 15,061 (184)

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

The Unfolding Action of GroEL on a Protein Substrate [PDF]

Biophysical Journal, 2004
A molecular dynamics simulation of the active unfolding of denatured rhodanese by the chaperone GroEL is presented. The compact denatured protein is bound initially to the cis cavity and forms stable contacts with several of the subunits. As the cis ring apical domains of GroEL undergo the transition from the closed to the more open (ATP-bound) state ...
van der Vaart, Arjan, Ma, Jianpeng, Karplus, Martin   +2 more
openaire   +2 more sources

High prevalence of a host‐associated Anaplasma lineage in wild coatis (Nasua nasua) from the Brazilian Atlantic Forest

Medical and Veterinary Entomology, EarlyView.
Anaplasma sp. DNA was detected in 47.9% of free‐ranging coatis (Nasua nasua) sampled in Iguaçu National Park, southern Brazil. Molecular analyses revealed a genetically distinct Anaplasma lineage infecting coatis, differing from Anaplasma strains detected in associated tick populations.
Matheus Dias Cordeiro, Paulo César Magalhães‐Matos, Isadora dos Santos Dias, Jônathan David Ribas Chagas, Olívia Zen Gianfrancisco, Ellen Meireles Brandão, Claudia Bezerra da Silva, Bruna de Azevedo Baêta   +7 more
wiley   +1 more source

Визначення та характеристика факторів ризику виникнення невиношування вагітності в жінок першого триместру гестації

Український журнал Здоров'я жінки
Ультразвукове дослідження (УЗД) відіграє вагому роль у діагностуванні загрози переривання вагітності (ЗПВ). Зміна структури міометрію, патологічні ЕХО-включення, морфологічні зміни додатків, вкорочення довжини шийки матки, відкриття внутрішнього вічка ...
N.A. Rynda-Dzuriy, D.O. Govsieiev
doaj   +1 more source

Porphyromonas gingivalis GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function

Molecular Oral Microbiology, EarlyView.
Abstract Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porphyromonas gingivalis can infiltrate remote organs via the bloodstream, thereby intensifying the severity ...
Chien‐Sung Tsai, Chun‐Yao Huang, Yi‐Ting Tsai, Chun‐Ming Shih, Ze‐Hao Lai, Chen‐Wei Liu, Yi‐Wen Lin, Feng‐Yen Lin   +7 more
wiley   +1 more source

Сироваткові рівні HSP60 і GroEL як біомаркери ризику невиношування вагітності в жінок І триместру гестації

Український журнал Перинатологія і педіатрія
Невиношування вагітності (НВ) залишається однією з провідних причин репродуктивних втрат у світі та в Україні. Незважаючи на прогрес у пренатальному діагностуванні, у 40–50% випадків етіологія НВ не встановлена, що підкреслює потребу в нових біомаркерах.
D.O. Govsieiev, N.A. Rynda-Dzyuriy, L.I. Martynova, O.L. Gromova   +3 more
doaj   +1 more source

Dataset concerning GroEL chaperonin interaction with proteins

Data in Brief, 2016
GroEL chaperonin is well-known to interact with a wide variety of polypeptide chains. Here we show the data related to our previous work (http://dx.doi.org/10.1016/j.pep.2015.11.020 [1]), and concerning the interaction of GroEL with native (lysozyme, α ...
V.V. Marchenkov, N.Yu. Marchenko, A.L. Kaysheva, N.V. Kotova, I.A. Kashparov, G.V. Semisotnov   +5 more
doaj   +1 more source

The Hydrophobic Nature of GroEL-Substrate Binding [PDF]

Journal of Biological Chemistry, 1995
The molecular chaperone GroEl from Escherichia coli is a member of the highly conserved Hsp60 family of proteins that facilitates protein folding. A central question regarding the mechanism of GroEL-assisted refolding of proteins concerns its broad substrate specificity.
Z, Lin, F P, Schwartz, E, Eisenstein
openaire   +2 more sources

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

GroEL/GroES Mechanism of Action and Formation of Complexes During Reaction Cycle: A Matter of Debate [PDF]

Journal of Stress Physiology & Biochemistry
The bacterial chaperonin GroEL alongwith its cochaperonin GroES is the paradigmatic molecular chaperone machine for protein folding. Most bacterial proteins require the GroEL chaperonin for proper folding.
Sutrisha Kundu, Vivek Raychaudhuri, Sudipa Saha   +2 more
doaj