Results 51 to 60 of about 19,683 (209)
BMEMat, EarlyView.Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen +9 more
wiley +1 more source
GroEL Binds to and Unfolds Rhodanese Posttranslationally [PDF]
Journal of Biological Chemistry, 1996 The Escherichia coli chaperone GroEL is a member of a class of molecular chaperones that possesses a stacked double ring structure containing seven subunits per ring, with approximately 60-kDa subunits. It has been suggested that newly synthesized proteins may interact with a eukaryotic homolog of GroEL co-translationally, thereby sequestering the ...
B G, Reid, G C, Flynn
openaire +2 more sources
GroEL ring separation and exchange in the chaperonin reaction [PDF]
, 2019 The bacterial chaperonin GroEL and its cofactor GroES form a nano-cage for a single molecule of substrate protein (SP) to fold in isolation. GroEL and GroES undergo an ATP-regulated interaction cycle that governs the closing and opening of the folding ...
Yan, Xiao, Yan, X.
core +2 more sources
Mass Spectrometry Reviews, EarlyView.ABSTRACT Top‐down proteomics (TDP) characterizes proteoforms in cells, tissues, and biofluids, in discovery mode and on a global scale, requiring analytical tools with high peak capacity for proteoform separation and high sensitivity for proteoform detection, given the extremely high proteoform complexity and wide proteoform concentration dynamic range.
Guijie Zhu +5 more
wiley +1 more source
Pest Management Science, EarlyView.Novel edodine was identified from Lentinula edodes HK761, exhibiting biocontrol potential against fire blight by affecting motility, intracellular ATP level, and cell division of Erwinia amylovora. Abstract BACKGROUND In the search for biological resources with antibacterial activity against Erwinia amylovora, the culture filtrate of Lentinula edodes ...
Yeong Seok Kim +7 more
wiley +1 more source
Gut microbiota dysbiosis and Long COVID susceptibility in chronic kidney disease
VIEW, EarlyView.This study investigated gut microbiota dysbiosis and its association with Long COVID susceptibility in 224 hemodialysis patients. We found that 35.3% of patients developed Long COVID, characterized by neurological symptoms and elevated inflammatory markers, accompanied by significant gut microbiota alterations including enriched proinflammatory taxa ...
Meiling Jin +5 more
wiley +1 more source
The Unfolding Action of GroEL on a Protein Substrate [PDF]
Biophysical Journal, 2004 A molecular dynamics simulation of the active unfolding of denatured rhodanese by the chaperone GroEL is presented. The compact denatured protein is bound initially to the cis cavity and forms stable contacts with several of the subunits. As the cis ring apical domains of GroEL undergo the transition from the closed to the more open (ATP-bound) state ...
van der Vaart, Arjan +2 more
openaire +2 more sources
Evolvability of Chaperonin Substrate Proteins [PDF]
, 2009 Molecular chaperones ensure that their substrate proteins reach the functional native state, and prevent their aggregation. Recently, an additional function was proposed for molecular chaperones: they serve as buffers (_capacitors_) for evolution by ...
Tobias Maier +7 more
core
Український журнал Здоров'я жінкиУльтразвукове дослідження (УЗД) відіграє вагому роль у діагностуванні загрози переривання вагітності (ЗПВ). Зміна структури міометрію, патологічні ЕХО-включення, морфологічні зміни додатків, вкорочення довжини шийки матки, відкриття внутрішнього вічка ...
N.A. Rynda-Dzuriy, D.O. Govsieiev
doaj +1 more source
Bacterial Heat Shock Protein GroEL (Hsp64) Exerts Immunoregulatory Effects on T Cells by Utilizing Apoptosis. [PDF]
PLoS ONE, 2016 Aggregatibacter actinomycetemcomitans (Aa) expresses a 64-kDa GroEL protein belonging to the heat shock family of proteins. This protein has been shown to influence human host cells, but the apoptotic capacity of the GroEL protein regarding T cells is ...
Ayten Nalbant, Melis Kant
doaj +1 more source