Results 81 to 90 of about 23,791 (224)

Breaking barriers: transitioning from X‐ray crystallography to cryo‐EM for structural studies

Acta Crystallographica Section D, Volume 82, Issue 3, Page 253-273, March 2026.
This article describes the transition of the Glass laboratory from X‐ray crystallography to single‐particle cryo‐electron microscopy (cryo‐EM) for structural studies of ATAD2B, a large AAA+ ATPase‐ and bromodomain‐containing protein involved in chromatin regulation.
Hassan Zafar, Kiera L. Malone, Ajit K. Singh, Michael A. Cianfrocco, Karen C. Glass   +4 more
wiley   +1 more source

Selection, phenotyping and identification of acid and hydrogen peroxide producing bacteria from vaginal samples of Canadian and East African women. [PDF]

PLoS ONE, 2012
The common but poorly understood condition known as bacterial vaginosis (BV) increases vulnerability to HIV infection and is associated with the absence of H(2)O(2)-producing Lactobacillus. Vaginal lactic acid bacteria (LAB) produce anti-HIV factors such
John J Schellenberg, Tim J Dumonceaux, Janet E Hill, Joshua Kimani, Walter Jaoko, Charles Wachihi, Jane Njeri Mungai, Margo Lane, Keith R Fowke, T Blake Ball, Francis A Plummer   +10 more
doaj   +1 more source

Exposure of Bifidobacterium longum subsp. infantis to Milk Oligosaccharides Increases Adhesion to Epithelial Cells and Induces a Substantial Transcriptional Response [PDF]

, 2013
Devon Kavanaugh is in receipt of a Teagasc Walsh Fellowship. The authors would also like to acknowledge the support of Science Foundation Ireland under Grant No.
Butto, Ludovica F., Clyne, Marguerite, Hickey, Rita M., Joshi, Lokesh, Kane, Marian, Kavanaugh, Devon W., Lane, Jonathan, O'Callaghan, John, Slattery, Helen   +8 more
core   +3 more sources

Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target

Aging Cell, Volume 25, Issue 3, March 2026.
By a global proteomic profiling of senescent human BJ fibroblasts induced by ionizing radiation, key cellular features required for the survival of senescent fibroblasts were revealed, and pyruvate dehydrogenase was demonstrated as a potent senolytic target for selectively eliminating senescent normal cells, particularly the therapy‐induced senescent ...
Mingzhu Zhang, Ziqi Hu, Shengwen Piao, Yingrui Song, Ying Jia, Jiaxing Liu, Ning Zhao, An Liu, Songbin Fu, Wenjing Sun, Hui Xu, Yu Yang, Steven P. Gygi, Chunshui Zhou   +13 more
wiley   +1 more source

A Study of the Vaginal Microbiome in Healthy Canadian Women Utilizing cpn60-Based Molecular Profiling Reveals Distinct Gardnerella Subgroup Community State Types. [PDF]

PLoS ONE, 2015
The vaginal microbiota is important in women's reproductive and overall health. However, the relationships between the structure, function and dynamics of this complex microbial community and health outcomes remain elusive.
Arianne Y K Albert, Bonnie Chaban, Emily C Wagner, John J Schellenberg, Matthew G Links, Julie van Schalkwyk, Gregor Reid, Sean M Hemmingsen, Janet E Hill, Deborah Money, VOGUE Research Group   +10 more
doaj   +1 more source

Phytosulfokine signalling blocks mycotoxin toxicity in Arabidopsis and mediates suppression of cell death activated by bacterial microbe‐associated molecular patterns

New Phytologist, Volume 249, Issue 5, Page 2515-2530, March 2026.
Summary Fumonisin B1 (FB1) is a mycotoxin that disrupts ceramide biosynthesis and kills plants. Prior activation with bacterial microbe‐associated molecular patterns (MAMPs), such as components of bacterial flagella, effectively suppresses FB1‐induced cell death.
Ali O. Alqarni, John M. U. Hamilton, Adrian P. Brown, Stephen Chivasa   +3 more
wiley   +1 more source

A Study of the Infant Nasal Microbiome Development over the First Year of Life and in Relation to Their Primary Adult Caregivers Using cpn60 Universal Target (UT) as a Phylogenetic Marker. [PDF]

PLoS ONE, 2016
Whereas the infant gut microbiome is the subject of intense study, relatively little is known regarding the nares microbiome in newborns and during early life.
Shelley W Peterson, Natalie C Knox, George R Golding, Shaun D Tyler, Andrea D Tyler, Philip Mabon, Joanne E Embree, Fiona Fleming, Sergio Fanella, Gary Van Domselaar, Michael R Mulvey, Morag R Graham   +11 more
doaj   +1 more source

Purification and characterization of chaperonins 60 and 10 from Methylobacillus glycogenes

Cell Stress & Chaperones, 1998
Two proteins belonging to the group I chaperonin family were isolated from an obligate methanotroph, Methylobacillus glycogenes. The two proteins, one a GroEL homologue (cpn60: M. glycogenes 60 kDa chaperonin) and the other a GroES homologue (cpn10: M. glycogenes 10 kDa chaperonin), composed a heteropolymeric complex in the presence of ATP.
Y, Kawata, K, Doi, H, Omoto, T, Mizobata, J, Nagai   +4 more
openaire   +3 more sources

Heat Shock Proteins in Aquatic Larvae: Nutritional and Live Feed Modulation of Chaperone‐Mediated Stress Physiology in Fish and Shellfish

Reviews in Aquaculture, Volume 18, Issue 2, March 2026.
ABSTRACT Heat shock proteins (HSPs) are highly conserved molecular chaperones that maintain proteostasis under environmental and physiological stress. In aquaculture research, HSP responses have been studied primarily in relation to temperature, salinity, pollutants, and pathogens in juvenile and adult stages, whereas the nutritional regulation of HSP ...
Yathish Ramena, Ram babu Kurapati, Thomas Bosteels, Grace Ramena   +3 more
wiley   +1 more source

Gardnerella vaginalis Subgroups Defined by cpn60 Sequencing and Sialidase Activity in Isolates from Canada, Belgium and Kenya. [PDF]

PLoS ONE, 2016
Increased abundance of Gardnerella vaginalis and sialidase activity in vaginal fluid is associated with bacterial vaginosis (BV), a common but poorly understood clinical entity associated with poor reproductive health outcomes.
John J Schellenberg, Teenus Paramel Jayaprakash, Niradha Withana Gamage, Mo H Patterson, Mario Vaneechoutte, Janet E Hill   +5 more
doaj   +1 more source