Results 61 to 70 of about 18,980 (171)

Multiple Chaperone DnaK–FliC Flagellin Interactions are Required for Pseudomonas aeruginosa Flagellum Assembly and Indicate a New Function for DnaK

open access: yesMicrobial Biotechnology, Volume 18, Issue 2, February 2025.
The dogma on the heat shock DnaK chaperone establishes its fundamental cytosolic role in folding and unfolding intracellular proteins. This study reveals its tight association with the flagellin, its secretion, likely through the flagellum apparatus, its insertion into a growing flagellum filament and a novel extracellular ATP‐independent chaperone ...
Gabriella Molinari   +17 more
wiley   +1 more source

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas [PDF]

open access: yes, 2018
This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with ...
Abdel-Rahman, Mohamed H.   +784 more
core   +2 more sources

Joint Analysis of Multiple Omics to Describe the Biological Characteristics of Resistant Hypertension

open access: yesThe Journal of Clinical Hypertension, Volume 27, Issue 1, January 2025.
Abstract Resistant hypertension (RH) may cause severe target organ damage and poses significant challenges in the field of hypertension prevention and treatment. Mining biological characteristics is crucial for exploring the pathogenesis of RH and for early diagnosis and treatment.
Shanshan Wang   +8 more
wiley   +1 more source

Extracellular Vesicles from Neurosurgical Aspirates Identifies Chaperonin Containing TCP1 Subunit 6A as a Potential Glioblastoma Biomarker with Prognostic Significance

open access: yesProteomics, 2019
Glioblastoma, WHO‐grade IV glioma, carries a dismal prognosis owing to its infiltrative growth and limited treatment options. Glioblastoma‐derived extracellular vesicles (EVs; 30–1000 nm membranous particles) influence the microenvironment to mediate ...
S. Hallal   +8 more
semanticscholar   +1 more source

Bag‐1‐mediated HSF1 phosphorylation regulates expression of heat shock proteins in breast cancer cells

open access: yesFEBS Open Bio, Volume 14, Issue 9, Page 1559-1569, September 2024.
We demonstrate that Bcl‐2‐associated athanogene (Bag)‐1 overexpression promotes human epidermal growth factor receptor 2 expression, thereby resulting in the activation of the heat shock factor‐1 (HSF1)–heat shock protein (HSP) axis. Our results suggest that Bag‐1 can modulate the chaperone activity of HSPs, by directly or indirectly regulating the ...
Tugba Kizilboga   +4 more
wiley   +1 more source

Protein phosphatase beta, a putative type-2A protein phosphatase from the human malaria parasite Plasmodium falciparum. [PDF]

open access: yes, 1997
Protein phosphatases play a critical role in the regulation of the eukaryotic cell cycle and signal transduction. A putative protein serine/threonine phosphatase gene has been isolated from the human malaria parasite Plasmodium falciparum.
Arndt K. T.   +32 more
core   +1 more source

Cytonuclear interplay in auto‐ and allopolyploids: a multifaceted perspective from the Festuca‐Lolium complex

open access: yesThe Plant Journal, Volume 118, Issue 4, Page 1102-1118, May 2024.
Significance Statement We provide insights into the restoration of the cytonuclear stoichiometry in the wake of a whole‐genome duplication and intergeneric hybridization in plants, here in ryegrass and fescue species and their intergeneric hybrids. By revealing species‐specific nuances and emphasizing the effect of the organelle genome copies, gene ...
Mehrdad Shahbazi   +12 more
wiley   +1 more source

Use of -induced antigen technology (IVIAT) for the identification of serotype 2 -induced bacterial protein antigens [PDF]

open access: yes, 2009
Background Streptococcus suis serotype 2 (SS2) is a zoonotic agent that causes death and disease in both humans and swine. A better understanding of SS2-host molecular interactions is crucial for understanding SS2 pathogenesis and immunology ...
Lu Chengping, Zhu Haodan, Gu Hongwei
core   +1 more source

Proteomic and Physiological Analyses Reveal Putrescine Responses in Roots of Cucumber Stressed by NaCl [PDF]

open access: yes, 2016
Soil salinity is a major environmental constraint that threatens agricultural productivity. Different strategies have been developed to improve crop salt tolerance, among which the effects of polyamines have been well-reported.
Jin Sun   +5 more
core   +1 more source

Dissection of the Bradyrhizobium japonicum NifA+σ54 regulon, and identification of a ferredoxin gene ( fdxN ) for symbiotic nitrogen fixation [PDF]

open access: yes, 2018
Hierarchically organized regulatory proteins form a complex network for expression control of symbiotic and accessory genes in the nitrogen-fixing soybean symbiont Bradyrhizobium japonicum.
Fischer, Hans-Martin   +7 more
core  

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