Results 51 to 60 of about 18,980 (171)

Transcriptome profiling of megakaryocytes and platelets: Application to GP9‐ and IKZF5‐related thrombocytopenia

open access: yesHemaSphere, Volume 9, Issue 9, September 2025.
Abstract Platelets are anucleate cells produced in the bone marrow and derived from large progenitor cells called megakaryocytes (MKs). Platelets receive RNA transcripts from their progenitorial MKs during thrombopoiesis. However, the correspondence between platelet and MK transcriptomes is poorly understood, particularly in the context of germline ...
Koenraad De Wispelaere   +7 more
wiley   +1 more source

Investigations on the microbial catabolism of the organic sulfur compounds TDP and DTDP in H16 employing DNA microarrays [PDF]

open access: yes, 2010
In this study, we have investigated the transcriptome of Ralstonia eutropha H16 during cultivation with gluconate in presence of 3,3'-thiodipropionic acid (TDP) or 3,3'-dithiodipropionic acid (DTDP) during biosynthesis of poly(3-hydroxybutyrate-co-3 ...
Alexander Steinbüchel   +4 more
core   +2 more sources

Chaperonin-containing TCP-1 subunit genes are potential prognostic biomarkers and are correlated with Th2 cell infiltration in lung adenocarcinoma: An observational study

open access: yesMedicine
A family of molecular chaperone complexes called chaperonin-containing T-complex protein 1 (TCP-1) subunit genes (CCTs) aids in the folding of numerous proteins.
Ruijuan Du   +6 more
semanticscholar   +1 more source

Avian Chaperonin Containing TCP1 Subunit 5 Supports Influenza A Virus Replication by Interacting With Viral Nucleoprotein, PB1, and PB2 Proteins

open access: yesFrontiers in Microbiology, 2020
Humans and avian species are prone to influenza viral infection, which may cause serious clinical consequences. Many studies have documented the critical role of host factors in the influenza virus life cycle based on human models, but knowledge about ...
Xiaohan Zhang   +6 more
semanticscholar   +1 more source

Quorum Sensing via Autoinducer‐2 Promotes Colonisation and Host Adaptation in B. bifidum PRL2010

open access: yesMicrobial Biotechnology, Volume 18, Issue 9, September 2025.
Autoinducer‐2 (AI‐2), encoded by the luxS gene, is a molecule involved in the quorum sensing mechanism in bifidobacteria, typical intestinal bacteria. In this manuscript, the distribution of this gene in all bifidobacterial genomes deposited in the database has been studied.
Francesca Turroni   +11 more
wiley   +1 more source

Comprehensive analysis of the expression of chaperonin containing TCP1 subunits (CCTs) and their influence on prognosis in hepatocellular carcinoma

open access: yesTranslational Cancer Research, 2020
Background Chaperonin containing TCP1 subunits (CCTs) are important components in the folding of newly synthesized proteins and are involved in cell growth, proliferation, and apoptosis in eukaryotes. Accumulating evidence indicates that dysregulation of
Rong-dang Fu   +5 more
semanticscholar   +1 more source

Bioinformatic analyses in early host response to Porcine Reproductive and Respiratory Syndrome virus (PRRSV) reveals pathway differences between pigs with alternate genotypes for a major host response QTL [PDF]

open access: yes, 2016
GO term enrichment performed on all 10 dpi time by time comparisons. For every time by time comparison the Enrichment Score for the significant DAVID clusters as well as a description of these clusters is presented for up-regulated and down-regulated ...
Arun Kommadath   +14 more
core   +5 more sources

Exploring the human archaeome: its relevance for health and disease, and its complex interplay with the human immune system

open access: yesThe FEBS Journal, Volume 292, Issue 6, Page 1316-1329, March 2025.
This work investigates the archaeome, an essential segment of the human microbiome, focusing on its relationship with the immune system. Here, we outline the types of archaea across different body areas and underscore possible links to health issues, such as obesity and specific cancers.
Torben Kuehnast   +5 more
wiley   +1 more source

Personalized Medicine in Ocular Fibrosis: Myth or Future Biomarkers [PDF]

open access: yes, 2016
SIGNIFICANCE: Fibrosis-related events play a part in the pathogenesis or failure of treatment of virtually all the blinding diseases around the world, and also account for over 40% of all deaths.
Khaw, PT, Yu-Wai-Man, C
core   +1 more source

14‐3‐3σ restricts YY1 to the cytoplasm, promoting therapy resistance, and tumor progression in colorectal cancer

open access: yesInternational Journal of Cancer, Volume 156, Issue 3, Page 623-637, 1 February 2025.
What's new? 14‐3‐3σ functions as an oncogene in colorectal cancer and is associated with therapy resistance. However, the underlying mechanisms remain unclear. Here, the authors show that 14‐3‐3σ restricts the localization of the transcription factor YY1 to the cytoplasm, preventing it from repressing genes of the unfolded protein response pathway ...
Amol Lonare   +8 more
wiley   +1 more source

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