Results 71 to 80 of about 18,980 (171)

Heat shock protein-90-alpha, a prolactin-STAT5 target gene identified in breast cancer cells, is involved in apoptosis regulation [PDF]

, 2008
INTRODUCTION: The prolactin-Janus-kinase-2-signal transducer and activator of transcription-5 (JAK2-STAT5) pathway is essential for the development and the functional differentiation of the mammary gland.
A Kamal, A Matsumoto, A Yoshimura, AD Basso, AD Basso, AG Ramsay, AJ Vomachka, AM Sapozhnikov, AM Weaver, B Zsebik, Bernd Groner, BK Eustace, C Bole-Feysot, C Brisken, C Brooks, C Coghlin, C Patry, C Queitsch, Carrie S Shemanko, Christian Perotti, Christine T Parusel, CJ Ormandy, CJ Watson, CM Perks, CM Shaw-Bruha, CS Shemanko, CV Clevenger, DB Solit, DR Rhodes, E Ginsburg, E Iavnilovitch, E Pick, Edith Pfitzner, EP Rogakou, F Bertucci, F Gouilleux, F Verdier, GR Merlo, GR Merlo, GR Merlo, H Wakao, H Wakao, H Wennbo, J Beliakoff, J Djiane, J Galea-Lauri, J Harris, J Hutchinson, J Turkson, JP Bailey, Jörg Schultz, K Schorr, K Uchida, K Wang, KA al-Sakkaf, KL Schwertfeger, KU Wagner, L Neckers, L Whitesell, L Whitesell, LM Arendt, M Grzmil, M Neuspiel, M Poetsch, M Tuna, M Yano, M Yano, MJ Naylor, MJ Naylor, MV Blagosklonny, MV Powers, Nadine Böcher, NM Verrills, P Chakravarti, P Csermely, P Workman, P Workman, P Workman, Peer Bork, PN Munster, RK Ball, Ruixuan Liu, RW Clarkson, S Desrivières, S Gass, S Modi, S Sato, S Sharp, SA Abdelmagid, SB Cullinan, SC Teng, SL Rutherford, SR Oakes, SS Tworoger, SS Tworoger, SS Tworoger, T Decker, TA Rose-Hellekant, V Calo, V Radhika, W Wu, W Xu, WY Chen, X Liu, Y Cui, YP Wu, Z Hou, Z Nouhi   +107 more
core   +2 more sources

YoeB toxin is activated during thermal stress. [PDF]

, 2015
Type II toxin-antitoxin (TA) modules are thought to mediate stress-responses by temporarily suppressing protein synthesis while cells redirect transcription to adapt to environmental change.
Garza-Sánchez, Fernando, Hayes, Christopher S, Janssen, Brian D   +2 more
core   +1 more source

Molecular analysis of the diversity of vaginal microbiota associated with bacterial vaginosis [PDF]

, 2010
Background Bacterial vaginosis (BV) is an ecological disorder of the vaginal microbiota that affects millions of women annually, and is associated with numerous adverse health outcomes including pre-term birth and the acquisition of sexually ...
Xin Z Ling, Ming J Kong, Fang Liu, Bin H Zhu, Yi X Chen, Zhu Y Wang, Juan L Li, Karen E. Nelson, Xian Y Xia, Charlie Xiang   +9 more
core   +1 more source

Overexpression of chaperonin containing T-complex polypeptide subunit zeta 2 (CCT6b) suppresses the functions of active fibroblasts in a rat model of joint contracture

Journal of Orthopaedic Surgery and Research, 2019
BackgroundJoint contracture is a fibrous disease characterized as joint capsule fibrosis that results in joint dysfunction and disability. The purpose of this study was to analyze the biological activities of chaperonin containing T-complex polypeptide ...
Xiaoyou Yi, Zhe Wang, Jianhua Ren, Ze Zhuang, Kaihua Liu, Kun Wang, Ronghan He   +6 more
semanticscholar   +1 more source

Relating the metatranscriptome and metagenome of the human gut [PDF]

, 2014
Although the composition of the human microbiome is now wellstudied, the microbiota’s \u3e8 million genes and their regulation remain largely uncharacterized.
Boylan, Matthew R., Chan, Andrew T., Ciulla, Dawn, Earl, Ashlee M., Franzosa, Eric A., Garrett, Wendy S., Gevers, Dirk, Giannoukos, Georgia, Huttenhower, Curtis, Izard, Jacques, Morgan, Xochitl C., Reyes, Joshua, Segata, Nicola, Waldron, Levi   +13 more
core   +2 more sources

Involvement of T-complex protein 1-ring complex/chaperonin containing T-complex protein 1 (TRiC/CCT) in retrograde axonal transport through tau phosphorylation

Neural Regeneration Research, 2019
The cytosolic chaperonin T-complex protein 1-ring complex (TRiC) or chaperonin containing T-complex protein 1 (CCT) is essential in de novo folding of approximately 10% of the eukaryotic, newly translated polypeptides as well as misfolded proteins. There
Xu-Qiao Chen
semanticscholar   +1 more source

A genomic approach to the study of Tribolium castaneum genetics, development & evolution [PDF]

, 2004
During the last decade, Tribolium castaneum has become the insect of choice for comparative genetics and developmental studies outside of drosophilids. Until recently, most molecular studies have focused on the comparative analysis of early development ...
Savard, Joël
core  

Targeting chaperonin containing TCP1 (CCT) as a molecular therapeutic for small cell lung cancer

OncoTarget, 2017
Identifying new druggable targets is desired to meet the needs for effective cancer treatments. To this end, we previously reported the efficacy of a therapeutic peptide called CT20p that displays selective cytotoxicity through inhibition of a multi ...
Ana C. Carr, A. Khaled, R. Bassiouni, Orielyz Flores, Daniel Nierenberg, Hammad A. Bhatti, Priya Vishnubhotla, J. Perez, S. Santra, A. Khaled   +9 more
semanticscholar   +1 more source

Identification of prefoldin amplification (1q23.3-q24.1) in bladder cancer using comparative genomic hybridization (CGH) arrays of urinary DNA [PDF]

, 2016
Background: Array-CGH represents a comprehensive tool to discover genomic disease alterations that could potentially be applied to body fluids. In this report, we aimed at applying array-CGH to urinary samples to characterize bladder cancer.
Algaba, Ferran, Bellmunt Molins, Joaquim, 1959-, Cigudosa, Juan Cruz, González-Peramato, Pilar, Heredero, Oscar, López, Virginia, Serrano, Alvaro, Suela, Javier, Sánchez-Carbayo, Marta, Vidal-Bel, August   +9 more
core   +1 more source

The structure and evolution of eukaryotic chaperonin-containing TCP-1 and its mechanism that folds actin into a protein spring.

Biochemical Journal, 2018
Actin is folded to its native state in eukaryotic cytosol by the sequential allosteric mechanism of the chaperonin-containing TCP-1 (CCT). The CCT machine is a double-ring ATPase built from eight related subunits, CCT1-CCT8.
K. Willison
semanticscholar   +1 more source