Results 81 to 90 of about 1,651,705 (291)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Conceptualisation and exposition: a paradigm of character creation [PDF]

While the concept of the fictional character has been widely discussed at an interdisciplinary level, a foundational theory of character creation in Creative Writing is yet to follow.
Varotsi, Evangelia
core   +3 more sources

Protocol for a hybrid type 3 effectiveness-implementation trial of a pragmatic individual-level implementation strategy for supporting school-based prevention programming

Implementation Science
Background For approximately one in five children who have social, emotional, and behavioral (SEB) challenges, accessible evidence-based prevention practices (EBPPs) are critical.
Aaron R. Lyon, Clayton R. Cook, Madeline Larson, Maria L. Hugh, Alex Dopp, Corinne Hamlin, Peter Reinke, Mahasweta Bose, Amy Law, Roger Goosey, Annie Goerdt, Nicole Morrell, Alisha Wackerle-Hollman, Michael D. Pullmann   +13 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Characters of Finite Quasigroups V: Linear Characters

European Journal of Combinatorics, 1989
[Part IV, cf. ibid. 10, No.3, 257-263 (1989; Zbl 0669.20053.] Aspects of the structure of quasigroups with a unique non-linear basic character are investigated. For example, in Section 4 it is shown that the linear basic characters of a general quasigroup are well behaved under multiplication. They form an abelian group which then acts on the remaining
Kenneth W. Johnson, Jonathan D. H. Smith
openaire   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Report From the Social and Character Development Research Program [PDF]

, 2010
Report evaluating seven Social and Character Development (SACD) programs designed to positively impact behavior and academic performance of a cohort of elementary students during their third through fifth grade years (2004-2007).
Allen, Ruby, Doolittle, Emily
core  

Meneropong Fenomena Beragama di Zaman Postmodernisme

Indonesian Character Journal
This paper examines fundamental changes in religious practice and understanding in the postmodern era, where collective religious authority has shifted toward a more personal form of spirituality.
PRISKARDUS CANDRA
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Character Moxie prosocial lesson pilot

, 2021
This study is designed to assess whether students interacting with the WeBE animated videos and reflection questions grow in moral character strengths of perspective taking, empathy, and moral ...
Melinda Bier, Satabdi Samtani, Michael Park   +2 more
core   +1 more source