Results 61 to 70 of about 3,531,460 (340)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The role of beliefs about teaching and assessment as mediating variables between beliefs about the nature of mathematics and characteristics related to the teaching profession [PDF]

Journal of Pedagogical Research
The professional character of mathematics teachers is influenced not only by their ability to manage learning but also by their beliefs about the subjects they teach.
Mailizar Mailizar, Mutia Fariha, Rahmah Johar, Rini Oktavia   +3 more
doaj   +1 more source

Integrating Character Education Elementary Mathematics: A Systematic Review of Values, Pedagogical Strategies and Moral Outcomes

Al-Adzka: Jurnal Ilmiah Pendidikan Guru Madrasah Ibtidaiyah
While character education is widely promoted in elementary curricula, mathematics remains largely conceptualized as a value-neutral domain. Existing studies tend to focus on instructional tools rather than explaining how moral values are formed through ...
Bisri Musthofa, Hasanah Abd Khafidz, Intan Aulia Rakhmawati, Ahmad Sunoko   +3 more
doaj   +1 more source

A framework for designing mathematics instruction using comics at the primary school level

Journal of Research and Advances in Mathematics Education, 2020
Developing primary school students’ interest in and getting them motivated to learn mathematics has been a perennial focus of educators. The use of comics for classroom instruction is an area gaining more attention from educators.
Yun Li Lynnette Chu, Tin Lam Toh
doaj   +1 more source

Novel Linguistic Steganography Based on Character-Level Text Generation

Mathematics, 2020
With the development of natural language processing, linguistic steganography has become a research hotspot in the field of information security. However, most existing linguistic steganographic methods may suffer from the low embedding capacity problem.
Lingyun Xiang, Shuang Yang, Yuhang Liu, Qian Li, Chengzhang Zhu   +4 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

IMPLEMENTASI MODEL PEMBELAJARAN MATEMATIKA PENDIDIKAN SEKOLAH DASAR BERBASIS KEUNGGULAN LOKAL DI KABUPATEN ACEH TENGAH

Al Khawarizmi, 2019
Purpose of this study is to: to find out the objective conditions of local superiority in mathematics learning in elementary schools in Central Aceh Regency, to design mathematical learning models based on local superiority of class I students, and to ...
Rosliana Harahap, Nur Ainun Lubis, Nurmalina Nurmalina   +2 more
doaj   +1 more source

Building an Applicative Model of Integration-Interconnection of Mathematics and Islamic Sciences

JRPM (Jurnal Review Pembelajaran Matematika), 2022
The idea of scientific integration-interconnection initiated by Amin Abdullah still cannot be applied in pure science study programs. The unique and very formal character of mathematics causes almost all lecturers of the Department of Mathematics and ...
Muhammad Wakhid Musthofa, Malahayati
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source